Walker M M
Department of Histopathology, Imperial College of Science, Technology and Medicine, London, UK.
Gut. 2003 Jan;52(1):1-4. doi: 10.1136/gut.52.1.1.
Intestinal metaplasia (IM) of the stomach is a risk factor in developing intestinal-type gastric cancer and hence the question of reversibility is vital. There is emerging epidemiological evidence that with long term follow up, IM may be reversible although a combination of antioxidant agents and eradication of H pylori may be necessary to achieve this. The pathogenesis of IM is currently being elucidated and it is likely that a combination of bacterial, host, and environmental factors will be shown to lead to IM. In assessing gastric cancer risk, histochemical typing of IM will most probably be replaced by molecular markers.
胃的肠化生（IM）是发生肠型胃癌的一个危险因素，因此其可逆性问题至关重要。新出现的流行病学证据表明，经过长期随访，IM可能是可逆的，不过可能需要联合使用抗氧化剂并根除幽门螺杆菌才能实现这一点。IM的发病机制目前正在阐明，很可能是细菌、宿主和环境因素共同作用导致IM。在评估胃癌风险时，IM的组织化学分型很可能会被分子标志物所取代。
