为什么人们会用扑热息痛来自杀？
Why do people use paracetamol for suicide?
作者信息
Gazzard B G, Davis M, Spooner J, Williams R
出版信息
Br Med J. 1976 Jan 24;1(6003):212-3. doi: 10.1136/bmj.1.6003.212.
Abstract
A questionnaire to assess motives for choosing paracetamol as a suicidal agent was completed by 107 patients admitted after an overdose of the drug. None of the 48 patients interviewed would have chosen paracetamol had they known that there would be an interval of two to three days before the onset of serious symptoms. Only five of the patients had obtained the drug on prescription, but the remainder had obtained it easily from a retail pharmacy. There was no apparent reason for the preference for paracetamol. It would be difficult to restrict the availability of paracetamol, and educating the public about the effects of an overdose would be more appropriate.
摘要
一份用于评估选择对乙酰氨基酚作为自杀药物动机的调查问卷，由107名过量服用该药物后入院的患者填写。在接受访谈的48名患者中，如果他们知道在出现严重症状之前会有两到三天的间隔时间，就不会选择对乙酰氨基酚。只有5名患者是通过处方获得该药物的，但其余患者很容易就从零售药店买到了。选择对乙酰氨基酚似乎没有明显原因。限制对乙酰氨基酚的获取难度较大，而对公众进行过量服用后果的教育可能更为合适。
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2
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3
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