Gilbertson R J, Harris E, Pandey S K, Kelly P, Myers W
Department of Community Paediatrics, Stanley Health Centre, County Durham.
Arch Dis Child. 1996 Sep;75(3):194-8. doi: 10.1136/adc.75.3.194.
Paracetamol is the commonest agent employed in self poisoning, however it is not clear whether adolescents possess insight into the serious complications associated with its misuse. Using a one page questionnaire, the availability, usage, and knowledge of toxicity of paracetamol among 1147 American and British adolescents was assessed. Although 90% of all students recognised that paracetamol could kill, the great majority of students overestimated the lethal dose. In addition, while knowledge regarding side effects of paracetamol was poor the drug was widely available to, and used by, the study population. It is proposed that gross overestimation of the number of tablets required to kill, poor understanding of paracetamol side effects, and wide availability of the drug contribute to its frequent use in adolescent suicidal behaviour. The inclusion of some over-the-counter medications in school drug education programs in addition to tighter control of the availability of paracetamol may help reduce the problem of adolescent self poisoning.
对乙酰氨基酚是自我中毒中最常用的药物,然而尚不清楚青少年是否了解其滥用所带来的严重并发症。通过一份单页问卷,对1147名美国和英国青少年中对乙酰氨基酚的可得性、使用情况及毒性知识进行了评估。尽管所有学生中有90%认识到对乙酰氨基酚可能致命,但绝大多数学生高估了致死剂量。此外,虽然对乙酰氨基酚副作用的知识匮乏,但该药物在研究人群中广泛可得且被使用。有人提出,对致死所需药片数量的严重高估、对对乙酰氨基酚副作用的理解不足以及该药物的广泛可得性,都导致了其在青少年自杀行为中的频繁使用。除了加强对对乙酰氨基酚可得性的控制外,在学校药物教育项目中纳入一些非处方药可能有助于减少青少年自我中毒问题。