Karakiewicz Pierre I, Foulkes William, Tanguay Simon, Elhilali Mostafa M, Aprikian Armen G
Department of Surgery (Urology), McGill University, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A41.
J Urol. 2003 Jan;169(1):240-4. doi: 10.1016/S0022-5347(05)64077-3.
We assessed familial prostate and breast cancer in Quebec.
Using a self-administered mail survey we assessed the prevalence of prostate and breast cancer in first degree relatives of 1,633 men treated with prostatectomy for prostate cancer in the province of Quebec and in first degree relatives of 1,386 spouse controls.
The OR of familial breast cancer was 1.1 (95% CI 0.9 to 1.4). The OR of 3.0 (95% CI 2.5 to 3.6) recorded for prostate cancer was modified by francophone versus anglophone linguistic preference (OR 3.2, 95% CI 2.6, 3.9 versus 1.5, 95% CI 0.8 to 2.7, p = 0.02). Male sibship size was a statistically significant parameter modifying this association (p = 0.02), namely no brothers (OR 1.7, 95% CI 1.0 to 2.8), 1 or 2 (OR 3.1, 95% CI 2.2 to 4.3) and 3 or more (OR 3.9, 95% CI 2.9 to 5.2). Geographic regions of the province including and neighboring greater Montreal showed a lower OR than more peripheral regions (2.5, 95% CI 2.0 to 3.2 versus 4.1, 95% CI 2.9 to 5.7, p = 0.02).
Francophone men with large male sibships residing in remote areas may be at higher risk for familial prostate cancer and represent the ideal target for further efforts to determine the genetic component of prostate cancer in Quebec.
我们评估了魁北克省的家族性前列腺癌和乳腺癌情况。
通过自行填写的邮寄调查问卷，我们评估了魁北克省1633名因前列腺癌接受前列腺切除术的男性的一级亲属以及1386名配偶对照的一级亲属中前列腺癌和乳腺癌的患病率。
家族性乳腺癌的比值比为1.1（95%置信区间为0.9至1.4）。前列腺癌的比值比为3.0（95%置信区间为2.5至3.6），但根据说法语者与说英语者的语言偏好有所修正（比值比分别为3.2，95%置信区间为2.6至3.9；以及1.5，95%置信区间为0.8至2.7，p = 0.02）。男性同胞数量是改变这种关联的一个具有统计学意义的参数（p = 0.02），即没有兄弟（比值比为1.7，95%置信区间为1.0至2.8）、有1个或2个兄弟（比值比为3.1，95%置信区间为2.2至4.3）以及有3个或更多兄弟（比值比为3.9，95%置信区间为2.9至5.2）。该省包括大蒙特利尔及其周边地区的地理区域的比值比低于更偏远地区（分别为2.5，95%置信区间为2.0至3.2；以及4.1，95%置信区间为2.9至5.7，p = 0.02）。
居住在偏远地区且男性同胞数量较多的说法语男性可能患家族性前列腺癌的风险更高，是进一步努力确定魁北克省前列腺癌遗传成分的理想目标人群。
