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细胞信号传导联盟概述。

Overview of the Alliance for Cellular Signaling.

作者信息

Gilman Alfred G, Simon Melvin I, Bourne Henry R, Harris Bruce A, Long Rochelle, Ross Elliott M, Stull James T, Taussig Ronald, Bourne Henry R, Arkin Adam P, Cobb Melanie H, Cyster Jason G, Devreotes Peter N, Ferrell James E, Fruman David, Gold Michael, Weiss Arthur, Stull James T, Berridge Michael J, Cantley Lewis C, Catterall William A, Coughlin Shaun R, Olson Eric N, Smith Temple F, Brugge Joan S, Botstein David, Dixon Jack E, Hunter Tony, Lefkowitz Robert J, Pawson Anthony J, Sternberg Paul W, Varmus Harold, Subramaniam Shankar, Sinkovits Robert S, Li Joshua, Mock Dennis, Ning Yuhong, Saunders Brian, Sternweis Paul C, Hilgemann Donald, Scheuermann Richard H, DeCamp Dianne, Hsueh Robert, Lin Keng-Mean, Ni Yan, Seaman William E, Simpson Paul C, O'Connell Timothy D, Roach Tamara, Simon Melvin I, Choi Sangdun, Eversole-Cire Pamela, Fraser Iain, Mumby Marc C, Zhao Yingming, Brekken Deirdre, Shu Hongjun, Meyer Tobias, Chandy Grischa, Heo Won Do, Liou Jen, O'Rourke Nancy, Verghese Mary, Mumby Susanne M, Han Heping, Brown H Alex, Forrester Jeffrey S, Ivanova Pavlina, Milne Stephen B, Casey Patrick J, Harden T Kendall, Arkin Adam P, Doyle John, Gray Martha L, Meyer Tobias, Michnick Stephen, Schmidt Martin A, Toner Mehmet, Tsien Roger Y, Natarajan Madhusudan, Ranganathan Rama, Sambrano Gilberto R

机构信息

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

出版信息

Nature. 2002 Dec 12;420(6916):703-6. doi: 10.1038/nature01304.

DOI:10.1038/nature01304
PMID:12478301
Abstract

The Alliance for Cellular Signaling is a large-scale collaboration designed to answer global questions about signalling networks. Pathways will be studied intensively in two cells--B lymphocytes (the cells of the immune system) and cardiac myocytes--to facilitate quantitative modelling. One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community.

摘要

细胞信号转导联盟是一个大规模合作项目,旨在解答有关信号网络的全球性问题。将在两种细胞——B淋巴细胞(免疫系统细胞)和心肌细胞中深入研究信号通路,以促进定量建模。目标之一是推动各个实验室开展互补性研究;为便于实现这一目标,联盟的所有数据都可供整个研究界免费使用。

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