间日疟原虫巴拿马株在南美白狨猴中用于测试疟疾疫苗的潜力。

Potential of the Panama strain of Plasmodium vivax for the testing of malarial vaccines in Aotus nancymai monkeys.

作者信息

Collins William E, Sullivan JoAnn S, Galland G Gale, Williams Allison, Nace Douglas, Williams Tyrone

机构信息

Division of Parasitic Diseases and Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Chamblee, Georgia 30341, USA.

出版信息

Am J Trop Med Hyg. 2002 Nov;67(5):454-8. doi: 10.4269/ajtmh.2002.67.454.

DOI:10.4269/ajtmh.2002.67.454

PMID:12479543

Abstract

Aotus monkeys were infected with a strain of Plasmodium vivax from Panama to determine its potential for the testing of malarial vaccines. After sporozoite inoculation, 3 splenectomized Aotus nancymai that had been infected previously with Plasmodium falciparum and P. vivax had prepatent periods of 13, 15, and 15 days with maximum parasite counts of 12,726/microl, 5,310/microl, and 9,180/microl. Three other A. nancymai previously infected with P. falciparum only had prepatent periods of 17, 15, and 15 days with maximum parasite counts of 44,460/microl, 31,500/microl, and 42,660/microl. One monkey with no previous history of infection had a prepatent period of 14 days after sporozoite inoculation, and a maximum parasite count of 100,000/microl; detectable parasitemia persisted for almost 500 days with 13 recognizable peaks in the parasite count. Anopheles dirus, Anopheles freeborni, Anopheles stephensi, and Anopheles quadrimaculatus mosquitoes were readily infected with the Panama strain.

摘要

将夜猴感染来自巴拿马的一种间日疟原虫菌株，以确定其在疟疾疫苗测试中的潜力。接种子孢子后，3只先前感染过恶性疟原虫和间日疟原虫的脾切除南美白眉猴的潜隐期分别为13天、15天和15天，最高寄生虫计数分别为每微升12,726个、5,310个和9,180个。另外3只仅先前感染过恶性疟原虫的南美白眉猴的潜隐期分别为17天、15天和15天，最高寄生虫计数分别为每微升44,460个、31,500个和42,660个。一只无既往感染史的猴子在接种子孢子后的潜隐期为14天，最高寄生虫计数为每微升100,000个；可检测到的寄生虫血症持续了近500天，寄生虫计数出现了13个可识别的峰值。大劣按蚊、弗里博按蚊、斯氏按蚊和四斑按蚊很容易感染巴拿马菌株。