Collins William E, Sullivan Joann S, Strobert Elizabeth, Galland G Gale, Williams Allison, Nace Douglas, Williams Tyrone, Barnwell John W
Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Geographic Medicine and Health Promotion and Animal Resources Branches, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Am J Trop Med Hyg. 2009 Feb;80(2):228-35.
A review is presented on studies conducted in New World monkeys and chimpanzees with the Salvador I strain of Plasmodium vivax. This isolate has been adapted to Aotus and Saimiri (squirrel) monkeys and developed as a model for the testing of antimalarial vaccines. After the injection of 10,000 sporozoites, the median prepatent period in S. boliviensis monkeys was 21.5 days. In 103 sporozoite-induced infections in splenectomized monkeys, the median maximum parasite count ranged from 2,139 to 202,368/microL, with a median maximum parasite count of 48,174/microL. Median maximum parasite counts in Aotus lemurinus griseimembra, A. nancymaae, A. azarae boliviensis, and A. vociferans monkeys were 19,902, 18,390, 21,420, and 18,210/microL, respectively and ranged from 124 to 156,000/microL. Mosquito infections were readily obtained in different species of Anopheles mosquitoes. The S. boliviensis monkey and Salvador I strain seems suitable for the testing of sporozoite and liver stage vaccines but not for blood-stage vaccines against P. vivax unless adapted further in spleen-intact Saimiri boliviensis monkeys.
本文综述了在新大陆猴和黑猩猩中使用间日疟原虫萨尔瓦多I株进行的研究。该分离株已适应夜猴和松鼠猴，并被开发为抗疟疾疫苗测试的模型。注射10,000个子孢子后，玻利维亚松鼠猴的中位潜隐期为21.5天。在103例经子孢子诱导的脾切除猴感染中，最大寄生虫计数中位数范围为2,139至202,368/微升，最大寄生虫计数中位数为48,174/微升。灰肢夜猴、南氏夜猴、玻利维亚阿扎拉夜猴和叫夜猴的最大寄生虫计数中位数分别为19,902、18,390、21,420和18,210/微升，范围为124至156,000/微升。在不同种类的按蚊中很容易获得蚊感染。玻利维亚松鼠猴和萨尔瓦多I株似乎适合测试子孢子和肝期疫苗，但不适合测试针对间日疟原虫的血期疫苗，除非在脾脏完整的玻利维亚松鼠猴中进一步适应。
