阳光和季节对大脑中血清素代谢的影响。
Effect of sunlight and season on serotonin turnover in the brain.
作者信息
Lambert G W, Reid C, Kaye D M, Jennings G L, Esler M D
机构信息
Human Neurotransmitter Laboratory and Alfred and Baker Medical Unit, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Victoria 8008, Melbourne, Australia.
出版信息
Lancet. 2002 Dec 7;360(9348):1840-2. doi: 10.1016/s0140-6736(02)11737-5.
Alterations in monoaminergic neurotransmission in the brain are thought to underlie seasonal variations in mood, behaviour, and affective disorders. We took blood samples from internal jugular veins in 101 healthy men, to assess the relation between concentration of serotonin metabolite in these samples and weather conditions and season. We showed that turnover of serotonin by the brain was lowest in winter (p=0.013). Moreover, the rate of production of serotonin by the brain was directly related to the prevailing duration of bright sunlight (r=0.294, p=0.010), and rose rapidly with increased luminosity. Our findings are further evidence for the notion that changes in release of serotonin by the brain underlie mood seasonality and seasonal affective disorder.
大脑中单胺能神经传递的改变被认为是情绪、行为和情感障碍季节性变化的基础。我们从101名健康男性的颈内静脉采集血样，以评估这些样本中血清素代谢物浓度与天气状况和季节之间的关系。我们发现，大脑中血清素的周转率在冬季最低（p = 0.013）。此外，大脑中血清素的产生速率与明亮阳光的持续时间直接相关（r = 0.294，p = 0.010），并且随着光照度的增加而迅速上升。我们的研究结果进一步证明了这样一种观点，即大脑中血清素释放的变化是情绪季节性和季节性情感障碍的基础。
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