Suarez Edward C, Lewis James G, Kuhn Cynthia
Department of Psychiatry and Behavioral Sciences, Box 3328, Duke University Medical Center, Durham, NC 27110, USA.
Brain Behav Immun. 2002 Dec;16(6):675-84. doi: 10.1016/s0889-1591(02)00019-3.
Aggression, hostility, and anger significantly predict morbidity and mortality from atherosclerotic cardiovascular disease (ACVD). ACVD is believed to be an inflammatory disease characterized by increased expression of a number of proinflammatory cytokines, such as tumor necrosis factor (TNF)-alpha. This study examined the relation of aggression, hostility, and anger to monocyte-associated TNF-alpha expression following lipopolysaccharide (LPS) stimulation. Participants were 62 healthy, non-smoking men (aged 18-45 years). Hostility, anger, verbal, and physical aggression were assessed using the Buss-Perry aggression questionnaire (BPAQ). LPS-stimulated TNF-alpha expression was determined using dual-color flow cytometry gating for CD14(+) cells. After controlling for age, race, education, and alcohol use, scores on the hostility (p=.013), physical aggression (p=.010), and verbal aggression (p=.034) subscales, and the total score (p=.007) on the BPAQ were positively associated with LPS-stimulated TNF-alpha expression. The results suggest that hostility and aggression are associated with an increased expression of TNF-alpha, a cytokine implicated in ACVD.
攻击性、敌意和愤怒是动脉粥样硬化性心血管疾病（ACVD）发病和死亡的重要预测因素。ACVD被认为是一种炎症性疾病，其特征是多种促炎细胞因子表达增加，如肿瘤坏死因子（TNF）-α。本研究探讨了攻击性、敌意和愤怒与脂多糖（LPS）刺激后单核细胞相关TNF-α表达之间的关系。研究对象为62名健康、不吸烟的男性（年龄18 - 45岁）。使用布斯-佩里攻击性问卷（BPAQ）评估敌意、愤怒、言语攻击和身体攻击。通过双色流式细胞术对CD14(+)细胞进行门控，测定LPS刺激后的TNF-α表达。在控制年龄、种族、教育程度和饮酒情况后，BPAQ的敌意分量表得分（p = 0.013）、身体攻击分量表得分（p = 0.010）、言语攻击分量表得分（p = 0.034）以及总分（p = 0.007）与LPS刺激后的TNF-α表达呈正相关。结果表明，敌意和攻击行为与TNF-α表达增加有关，TNF-α是一种与ACVD相关的细胞因子。
