Yamori Yukio, Moriguchi Emilio H, Teramoto Takanori, Miura Ayako, Fukui Yutaka, Honda Kei-ich, Fukui Masakazu, Nara Yasuo, Taira Kazuhiko, Moriguchi Yukio
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Kyoto, Japan.
J Am Coll Nutr. 2002 Dec;21(6):560-3. doi: 10.1080/07315724.2002.10719255.
Some human studies and animal models of experimental osteoporosis have shown that soy isoflavones may be effective on bone health. In this study, we carried out an intervention study to explore the effects of dietary isoflavone on bone metabolism.
Forty healthy female postmenopausal Japanese immigrants living in Brazil were divided into two groups: isoflavone-administered (n = 20) or placebo (n = 20). Subjects in the isoflavone-administered group ingested 37.3 mg per day for 10 weeks. The collection of 24-hour urine and the measurement of bone stiffness were performed at 0 and 10 weeks. Urinary excretion of isoflavones and bone resorption markers were analyzed.
Urinary isoflavone excretion in the isoflavone-administered group was significantly increased at weeks 3 and 10. Urinary excretion of bone resorption markers was reduced in the isoflavone-administered group, while the placebo group did not show any significant reduction. Differences in levels of urinary isoflavones and bone resorption markers between the two groups were significant.
This study demonstrated that the bone resorption was associated with the intake of soy isoflavones in postmenopausal women, and continuous dietary intake of isoflavone may inhibit postmenopausal osteoporosis.
一些人体研究和实验性骨质疏松症动物模型表明，大豆异黄酮可能对骨骼健康有效。在本研究中，我们开展了一项干预研究，以探讨膳食异黄酮对骨代谢的影响。
40名居住在巴西的健康绝经后日本女性移民被分为两组：异黄酮摄入组（n = 20）和安慰剂组（n = 20）。异黄酮摄入组的受试者连续10周每天摄入37.3毫克异黄酮。在第0周和第10周收集24小时尿液并测量骨硬度。分析异黄酮的尿排泄量和骨吸收标志物。
异黄酮摄入组在第3周和第10周时尿异黄酮排泄量显著增加。异黄酮摄入组的骨吸收标志物尿排泄量减少，而安慰剂组未显示出任何显著减少。两组之间尿异黄酮和骨吸收标志物水平的差异显著。
本研究表明，绝经后女性的骨吸收与大豆异黄酮的摄入有关，持续膳食摄入异黄酮可能抑制绝经后骨质疏松症。
