Lee Hansongyi, Choue Ryowon, Lim Hyunjung
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, Korea.
Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Korea.
Nutr Res Pract. 2017 Jun;11(3):223-231. doi: 10.4162/nrp.2017.11.3.223. Epub 2017 Apr 20.
BACKGROUND/OBJECTIVES: Soy isoflavones are expected to improve menopausal symptoms and osteoporosis in women. However, their efficacy is still inconclusive, and there was limited data for postmenopausal women in South Korea. We examined the effects of soy isoflavones on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women.
SUBJECTS/METHODS: A randomized, double-blind study design was used. Eighty-seven participants who had undergone natural menopause were randomly administered either 70 mg/day isoflavones (n = 43) or placebo (n = 41) for 12 weeks. We assessed the Kupperman index for climacteric symptoms and the menopause-specific quality of life (MENQOL) questionnaire for quality of the life. Biomarkers of bone metabolism were also measured in serum bone-specific alkaline phosphatase (BALP), osteocalcin (OC), N- and C-terminal cross-linking telopeptides of type I collagen (NTx, CTx), and urine-deoxypyridinolin (u-DPD).
Scores of the Kupperman index were decreased in both the isoflavones group (-7.0 ± 15.8, = 0.0074) and placebo group (-6.3 ± 14.6, = 0.0064) during the intervention, but no significant difference was noted between the groups. Regarding the bone formation markers, the level of serum BALP increased by 6.3 ± 4.1% ( = 0.004) and OC increased by 9.3 ± 6.2% ( < 0.001), meanwhile those of the placebo were not changed. For the bone resorption markers, NTx, CTx, and u-DPD were not significantly different in either group. MENQOL was significant decreased in the isoflavone group (-0.6 ± 0.5) and placebo group (-0.6 ± 0.4), with a significant difference between groups ( = 0.0228).
Our study suggests that 70 mg isoflavones supplement has beneficial effects on bone formation markers; however, it showed no benefit compared to the placebo on climacteric symptoms or quality of life.
背景/目的：大豆异黄酮有望改善女性更年期症状和骨质疏松症。然而，其疗效仍不明确，且韩国绝经后女性的数据有限。我们研究了大豆异黄酮对韩国绝经后女性更年期症状、骨生物标志物和生活质量的影响。
受试者/方法：采用随机双盲研究设计。87名自然绝经的参与者被随机给予70毫克/天异黄酮（n = 43）或安慰剂（n = 41），为期12周。我们评估了更年期症状的库珀曼指数和生活质量的更年期特异性生活质量（MENQOL）问卷。还测量了血清骨特异性碱性磷酸酶（BALP）、骨钙素（OC）、I型胶原N端和C端交联端肽（NTx、CTx）以及尿脱氧吡啶啉（u-DPD）等骨代谢生物标志物。
干预期间，异黄酮组（-7.0±15.8，P = 0.0074）和安慰剂组（-6.3±14.6，P = 0.0064）的库珀曼指数评分均下降，但两组间无显著差异。关于骨形成标志物，血清BALP水平升高6.3±4.1%（P = 0.004），OC升高9.3±6.2%（P<0.001），而安慰剂组则无变化。对于骨吸收标志物，两组的NTx、CTx和u-DPD均无显著差异。MENQOL在异黄酮组（-0.6±0.5）和安慰剂组（-0.6±0.4）均显著下降，两组间有显著差异（P = 0.0228）。
我们的研究表明，70毫克异黄酮补充剂对骨形成标志物有有益作用；然而，与安慰剂相比，它在更年期症状或生活质量方面没有益处。
