Uesugi Takehiko, Fukui Yutaka, Yamori Yukio
Fujicco Co., Ltd., Kobe, Japan.
J Am Coll Nutr. 2002 Apr;21(2):97-102. doi: 10.1080/07315724.2002.10719200.
The aim of this study was to determine the effects of soy isoflavones with weak estrogen-like activities both on bone metabolism and on serum lipids in perimenopausal women.
Twenty-three healthy perimenopausal women were assigned randomly to either isoflavone or placebo groups. The isoflavone group (n = 12) received daily capsules of soy isoflavone extract (61.8 mg of isoflavones) and the placebo group (n = 11) received daily placebo capsules for four weeks. Urinary excretion of isoflavone was measured at weeks 0, 2 and 4. Urinary excretion of pyridinoline and deoxypyridinoline, bone stiffness and levels of serum cholesterol, triglyceride and cholesterol fractions were measured at weeks 0 and 4.
As compared to the placebo group, urinary isoflavone, primarily daidzein, excretion was increased at weeks 2 and 4 in the isoflavone group. Excretion of bone resorption markers was reduced significantly in the isoflavone group. Both total serum cholesterol and LDL cholesterol were decreased significantly in the isoflavone group. Other serum biochemical parameters were not changed in either group.
Soy isoflavone supplementation for four weeks showed potentially beneficial effects on bone metabolism and on serum lipids in perimenopausal women. These effects could have the potential to reduce the risks of postmenopausal osteoporosis and of cardiovascular diseases in such women.
本研究旨在确定具有弱雌激素样活性的大豆异黄酮对围绝经期女性骨代谢和血脂的影响。
23名健康的围绝经期女性被随机分为异黄酮组或安慰剂组。异黄酮组（n = 12）每天服用大豆异黄酮提取物胶囊（61.8毫克异黄酮），安慰剂组（n = 11）每天服用安慰剂胶囊，持续四周。在第0、2和4周测量异黄酮的尿排泄量。在第0和4周测量吡啶啉和脱氧吡啶啉的尿排泄量、骨硬度以及血清胆固醇、甘油三酯和胆固醇组分的水平。
与安慰剂组相比，异黄酮组在第2和4周时尿异黄酮（主要是大豆苷元）排泄量增加。异黄酮组骨吸收标志物的排泄量显著降低。异黄酮组血清总胆固醇和低密度脂蛋白胆固醇均显著降低。两组的其他血清生化参数均未改变。
为期四周的大豆异黄酮补充对围绝经期女性的骨代谢和血脂显示出潜在的有益影响。这些影响可能有降低此类女性绝经后骨质疏松症和心血管疾病风险的潜力。
