Fong Y C, Hsu H C, Sun S S, Kao A, Lin C C, Lee C C
Department of Orthopedics, China Medical College Hospital, No. 2 Yuh-Der Road, Taichung 404, Taiwan.
Abdom Imaging. 2003 Jan-Feb;28(1):87-91. doi: 10.1007/s00261-001-0180-y.
Patients with spinal cord injury (SCI) have increased prevalences of gallstones and acute acalculous cholecystitis. A possible explanation for the increased prevalence of gallstone disease in SCI patients is decreased gallbladder motility causing gallbladder stasis, a known risk factor for gallstone disease. We investigated gallbladder function in SCI.
Twenty-five normal control subjects and 50 SCI patients were included in this study. Gallbladder function was measured by technium 99m-labeled imino-diacetic acid analogue (Tc-99m DISIDA) cholescintigraphy and represented by the filling fraction (FF) and the ejection fraction (EF). The SCI patients were assigned to subgroups: old versus young, female versus male, high- versus low-level injury, and long versus short injury duration.
Forty-two percent of SCI patients had abnormal FFs and 54% of SCI patients had abnormal EFs. Significantly decreased FF and EF values were found in SCI patients, especially in those who were female and had high-level injuries.
With the use of quantitative Tc-99m DISIDA cholescintigraphy, we found that SCI can significantly impair gallbladder function.
脊髓损伤（SCI）患者胆结石和急性非结石性胆囊炎的患病率增加。SCI患者胆结石疾病患病率增加的一个可能解释是胆囊运动性降低导致胆囊淤滞，这是胆结石疾病的一个已知危险因素。我们研究了SCI患者的胆囊功能。
本研究纳入了25名正常对照者和50名SCI患者。通过锝99m标记的亚氨基二乙酸类似物（Tc-99m DISIDA）胆闪烁显像测量胆囊功能，并用充盈分数（FF）和排空分数（EF）表示。SCI患者被分为不同亚组：老年与青年、女性与男性、高位与低位损伤、损伤持续时间长与短。
42%的SCI患者FF异常，54%的SCI患者EF异常。SCI患者的FF和EF值显著降低，尤其是女性和高位损伤患者。
通过使用定量Tc-99m DISIDA胆闪烁显像，我们发现SCI可显著损害胆囊功能。
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