Yang Ching-Chiang, Sun Shung-Shung, Lin Cheng-Chieh, Kao Albert, Lee Cheng-Chun
Department of Urology, China Medicine College Hospital, Taichung, Taiwan
J Diabetes Complications. 2002 Sep-Oct;16(5):347-51. doi: 10.1016/s1056-8727(01)00218-5.
Non-insulin-dependent diabetes mellitus (NIDDM) is considered to predispose impaired gallbladder function and an increased prevalence of gallbladder disease. The aim of this study was to evaluate the gallbladder function of patients with NIDDM by quantitative technetium-99m-labeled imino-diacetic acid analogue (Tc-99m DISIDA) cholescintigraphy. One hundred and forty-five NIDDM patients (100 males, 45 females; age: 58.7+/-9.5 years) with the absence of autonomic or peripheral neuropathy and without gallbladder or liver disorders were enrolled in this study. The patients were categorized by blood sugar control (HbA(1c)> or =10% as a poor blood sugar control group and HbA(1c)<10% as a good blood sugar control group) and disease duration (diabetic duration > or =10 years as a longer-duration group and diabetic duration <10 years as a shorter-duration group). In addition, 60 normal controls (38 males, 22 females; age: 59.1+/-10.2 years) were also studied for comparison. All NIDDM patients and normal controls underwent Tc-99m DISIDA cholescintigraphy, and the filling fraction (FF) and ejection fraction (EF) of gallbladder were calculated. The results showed significant difference between (1) NIDDM patients versus normal controls in FF and EF, (2) poor versus good blood sugar control of NIDDM patients in FF and EF, and (3) longer versus shorter disease duration of NIDDM patients in FF and EF. Our study, including a large number of subjects, showed that gallbladder function of patients with NIDDM is more impaired than the normal controls; and impaired gallbladder function in NIDDM patients is related to disease duration and blood sugar control.
非胰岛素依赖型糖尿病（NIDDM）被认为易导致胆囊功能受损及胆囊疾病患病率增加。本研究旨在通过定量锝-99m标记亚氨基二乙酸类似物（Tc-99m DISIDA）胆系闪烁显像评估NIDDM患者的胆囊功能。本研究纳入了145例无自主神经或周围神经病变且无胆囊或肝脏疾病的NIDDM患者（男性100例，女性45例；年龄：58.7±9.5岁）。患者按血糖控制情况（糖化血红蛋白[HbA(1c)]≥10%为血糖控制差组，HbA(1c)<10%为血糖控制好组）和病程（糖尿病病程≥10年为病程长组，糖尿病病程<10年为病程短组）进行分类。此外，还研究了60例正常对照者（男性38例，女性22例；年龄：59.1±10.2岁）以作比较。所有NIDDM患者和正常对照者均接受了Tc-99m DISIDA胆系闪烁显像，并计算胆囊的充盈分数（FF）和排空分数（EF）。结果显示：（1）NIDDM患者与正常对照者在FF和EF方面存在显著差异；（2）NIDDM患者中血糖控制差与控制好者在FF和EF方面存在显著差异；（3）NIDDM患者中病程长与病程短者在FF和EF方面存在显著差异。我们纳入大量受试者的研究表明，NIDDM患者的胆囊功能比正常对照者受损更严重；且NIDDM患者胆囊功能受损与病程及血糖控制有关。
