Kao C H, Wang S J, Chen G H, Yeh S H
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Nucl Med Commun. 1994 Sep;15(9):742-5. doi: 10.1097/00006231-199409000-00013.
Thirteen patients with gallbladder sludge, 14 patients with gallstones and 24 control cases with normal gallbladders were included in the study. Gallbladder function was represented as the filling fraction (FF) and the ejection fraction (EF) calculated using quantitative 99Tcm-DISIDA cholescintigraphy and compared in the groups. The results showed that (1) the patients with normal gallbladders had the highest FF and EF, (2) those with gallstones had the lowest FF, (3) the patients with gallbladder sludge had the lowest EF, and (4) the coefficient of variation (CV) of FF and EF of the normal controls were less than those for the patients with gallstones or sludge. There was only a statistically significant difference between the normal controls and the patients with gallstones for FF. However, no significant differences existed among the three groups for EF. In our preliminary results, we found that gallbladder sludge or stones may impair gallbladder function, especially FF, as evidenced by noninvasive and quantitative 99Tcm-DISIDA cholescintigraphy, and the higher CV value suggests that gallbladder function in patients with gallstones or sludge is more variable.
本研究纳入了13例胆囊泥沙样结石患者、14例胆囊结石患者和24例胆囊正常的对照病例。胆囊功能通过使用定量99锝-二异丙基乙酰苯胺（99Tcm-DISIDA）肝胆闪烁显像计算的充盈分数（FF）和排空分数（EF）来表示，并在各组间进行比较。结果显示：（1）胆囊正常的患者FF和EF最高；（2）胆囊结石患者FF最低；（3）胆囊泥沙样结石患者EF最低；（4）正常对照组FF和EF的变异系数（CV）低于胆囊结石或泥沙样结石患者。FF方面，正常对照组与胆囊结石患者之间仅存在统计学显著差异。然而，三组间EF无显著差异。在我们的初步结果中，我们发现胆囊泥沙样结石或结石可能损害胆囊功能，尤其是FF，这通过无创定量99Tcm-DISIDA肝胆闪烁显像得到证实，且较高的CV值表明胆囊结石或泥沙样结石患者的胆囊功能更具变异性。
