Xia Chang-Suo, Yang Xuan-Ying, Hong Guang-Xiang
Department of Orthopaedics, Affiliated Hospital, Qingdao University Medical College, Qingdao, China.
Hepatobiliary Pancreat Dis Int. 2007 Apr;6(2):204-7.
Spinal cord injury (SCI) is associated with increased prevalence of gallstones and acute acalculous cholecystitis. A possible explanation for the increased prevalence of gallstones in SCI patients is decreased gallbladder motility causing gallbladder stasis. In this study, we investigated gallbladder function in patients with SCI.
Eighteen normal controls, 16 trauma controls and 46 SCI patients were included in this study. Gallbladder function was measured by technium 99m-labeled imino-diacetic acid analogue ((99)Tc(m)-DISIDA) hepatobiliary imaging and represented by filling fraction (FF) and ejection fraction (EF). The data from SCI patients were analyzed according to old versus young, female versus male, heavy versus light body weight, ASIA A & B versus ASIA C & D classification, high- versus low-level injury, and long versus short injury duration.
Fifty-two percent of SCI patients had abnormal FF and 59% had abnormal EF. Significantly decreased FF and EF values were found in SCI patients, especially in female patients with severe and high-level injuries.
Quantitative (99)Tc(m)-DISIDA cholescintigraphy showed that SCI can significantly impair gallbladder function.
脊髓损伤（SCI）与胆结石及急性非结石性胆囊炎的患病率增加有关。SCI患者胆结石患病率增加的一个可能解释是胆囊运动性降低导致胆囊淤滞。在本研究中，我们调查了SCI患者的胆囊功能。
本研究纳入了18名正常对照者、16名创伤对照者和46名SCI患者。通过锝99m标记的亚氨基二乙酸类似物（（99）Tc（m）-DISIDA）肝胆显像测量胆囊功能，并用充盈分数（FF）和排空分数（EF）表示。根据年龄老少、性别、体重轻重、美国脊髓损伤协会（ASIA）A&B级与ASIA C&D级分类、损伤平面高低以及损伤持续时间长短，对SCI患者的数据进行分析。
52%的SCI患者FF异常，59%的患者EF异常。在SCI患者中发现FF和EF值显著降低，尤其是重度和高位损伤的女性患者。
定量（99）Tc（m）-DISIDA胆系闪烁显像显示，SCI可显著损害胆囊功能。
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