Choi Seung Ho, Park Tae Gwan
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea.
J Biomater Sci Polym Ed. 2002;13(10):1163-73. doi: 10.1163/156856202320813864.
Various ABA-type tri-block copolymers composed of poly(L-lactide) (PLA) or poly (lactide-co-glycolide) (PLGA) as the side A block and poly(epsilon-caprolactone) (PCL) as the middle B block were synthesized to produce rapidly degrading elastic matrices useful for tissue engineering scaffolds. The terminal di-hydroxyl groups in PCL-diol (MW 2000) were used as the initiator for the ring-opening polymerization of L-lactide or D,L-lactide and glycolide, employing stannous octoate as a catalyst. A series of copolymers were synthesized by varying the chain length and monomer composition of the PLA (PLGA) block, while the chain length of the PCL block was fixed. It was found that PLGA/PCL/PLGA copolymers with a MW of 10000 and lactide/glycolide ratios of 50/50 and 75/25 demonstrated desirable mechanical properties of elasticity (Young's modulus 26.0 and 19.8 MPa) and showed controllable degradability over a 2-month period depending on the monomer composition.
合成了各种ABA型三嵌段共聚物，其由聚（L-丙交酯）（PLA）或聚（丙交酯-共-乙交酯）（PLGA）作为侧链A嵌段，聚（ε-己内酯）（PCL）作为中间B嵌段，以制备可用于组织工程支架的快速降解弹性基质。使用PCL-二醇（分子量2000）中的末端二羟基作为L-丙交酯或D，L-丙交酯与乙交酯开环聚合的引发剂，采用辛酸亚锡作为催化剂。通过改变PLA（PLGA）嵌段的链长和单体组成来合成一系列共聚物，而PCL嵌段的链长保持固定。发现分子量为10000且丙交酯/乙交酯比例为50/50和75/25的PLGA/PCL/PLGA共聚物表现出理想的弹性力学性能（杨氏模量分别为26.0和19.8MPa），并且根据单体组成在2个月的时间内显示出可控的降解性。
