• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用选择性激光烧结技术生产药物的最新进展

Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering.

作者信息

Balasankar Athinarayanan, Anbazhakan Kandasamy, Arul Velusamy, Mutharaian Velankadu Natrayan, Sriram Ganesan, Aruchamy Kanakaraj, Oh Tae Hwan, Ramasundaram Subramaniyan

机构信息

Department of Physics, Gobi Arts & Science College, Erode, Gobichettipalayam 638453, India.

Department of Chemistry, Sri Eshwar College of Engineering (Autonomous), Coimbatore 641202, India.

出版信息

Biomimetics (Basel). 2023 Jul 27;8(4):330. doi: 10.3390/biomimetics8040330.

DOI:10.3390/biomimetics8040330
PMID:37622935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10452903/
Abstract

Selective laser sintering (SLS) is an additive manufacturing process that has shown promise in the production of medical devices, including hip cups, knee trays, dental crowns, and hearing aids. SLS-based 3D-printed dosage forms have the potential to revolutionise the production of personalised drugs. The ability to manipulate the porosity of printed materials is a particularly exciting aspect of SLS. Porous tablet formulations produced by SLS can disintegrate orally within seconds, which is challenging to achieve with traditional methods. SLS also enables the creation of amorphous solid dispersions in a single step, rather than the multi-step process required with conventional methods. This review provides an overview of 3D printing, describes the operating mechanism and necessary materials for SLS, and highlights recent advances in SLS for biomedical and pharmaceutical applications. Furthermore, an in-depth comparison and contrast of various 3D printing technologies for their effectiveness in tissue engineering applications is also presented in this review.

摘要

选择性激光烧结（SLS）是一种增材制造工艺，已在医疗器械生产中展现出前景，这些医疗器械包括髋关节杯、膝关节托盘、牙冠和助听器。基于SLS的3D打印剂型有潜力彻底改变个性化药物的生产。能够控制打印材料的孔隙率是SLS一个特别令人兴奋的方面。通过SLS生产的多孔片剂配方可以在几秒钟内口服崩解，而用传统方法很难做到这一点。SLS还能够一步制备无定形固体分散体，而不是传统方法所需的多步过程。本文综述概述了3D打印，描述了SLS的操作机制和所需材料，并重点介绍了SLS在生物医学和制药应用方面的最新进展。此外，本文还深入比较和对比了各种3D打印技术在组织工程应用中的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/2e2477e5c30c/biomimetics-08-00330-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/f6cc24ff830c/biomimetics-08-00330-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/52802113308b/biomimetics-08-00330-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/7d830b35b2ec/biomimetics-08-00330-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/aa9b6e4ed7b1/biomimetics-08-00330-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/24602be5ba15/biomimetics-08-00330-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/2b8b1ba092e1/biomimetics-08-00330-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/2e2477e5c30c/biomimetics-08-00330-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/f6cc24ff830c/biomimetics-08-00330-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/52802113308b/biomimetics-08-00330-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/7d830b35b2ec/biomimetics-08-00330-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/aa9b6e4ed7b1/biomimetics-08-00330-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/24602be5ba15/biomimetics-08-00330-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/2b8b1ba092e1/biomimetics-08-00330-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d01/10452903/2e2477e5c30c/biomimetics-08-00330-g007.jpg

相似文献

1
Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering.使用选择性激光烧结技术生产药物的最新进展
Biomimetics (Basel). 2023 Jul 27;8(4):330. doi: 10.3390/biomimetics8040330.
2
Selective Laser Sintering (SLS), a New Chapter in the Production of Solid Oral Forms (SOFs) by 3D Printing.选择性激光烧结（SLS），3D打印固体口服制剂（SOFs）生产的新篇章。
Pharmaceutics. 2021 Aug 6;13(8):1212. doi: 10.3390/pharmaceutics13081212.
3
Synergistic application of twin-screw granulation and selective laser sintering 3D printing for the development of pharmaceutical dosage forms with enhanced dissolution rates and physical properties.双螺杆造粒和选择性激光烧结 3D 打印的协同应用，开发具有增强溶解速率和物理性能的药物剂型。
Eur J Pharm Biopharm. 2021 Jun;163:141-156. doi: 10.1016/j.ejpb.2021.03.016. Epub 2021 Apr 8.
4
Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous Solid Dispersions.激光速度和药物粒径对非晶态固体分散体选择性激光烧结3D打印的影响
Pharmaceutics. 2021 Jul 27;13(8):1149. doi: 10.3390/pharmaceutics13081149.
5
Prediction of Solid-State Form of SLS 3D Printed Medicines Using NIR and Raman Spectroscopy.利用近红外光谱和拉曼光谱预测选择性激光烧结3D打印药物的固态形式
Pharmaceutics. 2022 Mar 8;14(3):589. doi: 10.3390/pharmaceutics14030589.
6
Investigating the Use of Magnetic Nanoparticles As Alternative Sintering Agents in Selective Laser Sintering (SLS) 3D Printing of Oral Tablets.研究磁性纳米颗粒作为选择性激光烧结（SLS）3D 打印口腔片剂的替代烧结剂的应用。
ACS Biomater Sci Eng. 2023 Jun 12;9(6):2924-2936. doi: 10.1021/acsbiomaterials.2c00299. Epub 2023 Feb 6.
7
Fabricating 3D printed orally disintegrating printlets using selective laser sintering.使用选择性激光烧结技术制造 3D 打印口腔崩解打印片。
Int J Pharm. 2018 Apr 25;541(1-2):101-107. doi: 10.1016/j.ijpharm.2018.02.015. Epub 2018 Feb 14.
8
3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering.使用选择性激光烧结技术3D打印个性化卡维地洛片剂
Pharmaceutics. 2023 Aug 29;15(9):2230. doi: 10.3390/pharmaceutics15092230.
9
Cold Laser Sintering of Medicines: Toward Carbon Neutral Pharmaceutical Printing.药物的冷激光烧结：迈向碳中和药物打印
ACS Sustain Chem Eng. 2024 Jul 16;12(30):11155-11166. doi: 10.1021/acssuschemeng.4c01439. eCollection 2024 Jul 29.
10
3D printing: Principles and pharmaceutical applications of selective laser sintering.3D 打印：选择性激光烧结的原理及药物应用。
Int J Pharm. 2020 Aug 30;586:119594. doi: 10.1016/j.ijpharm.2020.119594. Epub 2020 Jul 2.

引用本文的文献

1
3D Printing in Oral Drug Delivery: Technologies, Clinical Applications and Future Perspectives in Precision Medicine.3D打印在口服药物递送中的应用：精准医学中的技术、临床应用及未来展望
Pharmaceuticals (Basel). 2025 Jun 28;18(7):973. doi: 10.3390/ph18070973.
2
Printabily of Pharmaceutical-Grade Polymers using Selective Laser Sintering with a CO Laser.使用CO激光器通过选择性激光烧结制备药用级聚合物的可印刷性
AAPS PharmSciTech. 2025 May 22;26(5):144. doi: 10.1208/s12249-025-03141-4.
3
Pharmacokinetic assessment and level-A IVIVC establishment of rifampicin-loaded 3D printed tablets using SLS 3D printing.

本文引用的文献

1
3D printing and 3D-printed electronics: Applications and future trends in smart drug delivery devices.3D打印与3D打印电子产品：智能药物递送装置中的应用及未来趋势
Int J Bioprint. 2023 Apr 4;9(4):725. doi: 10.18063/ijb.725. eCollection 2023.
2
A Review on Physicochemical Properties of Polymers Used as Filaments in 3D-Printed Tablets.聚合物的物理化学性质综述：作为 3D 打印片剂中丝材的应用。
AAPS PharmSciTech. 2023 May 9;24(5):116. doi: 10.1208/s12249-023-02570-3.
3
Additive manufacturing technologies with emphasis on stereolithography 3D printing in pharmaceutical and medical applications: A review.
使用选择性激光烧结3D打印技术对载利福平3D打印片剂进行药代动力学评估及建立A级体内体外相关性
Ther Deliv. 2025 Jun;16(6):535-544. doi: 10.1080/20415990.2025.2484169. Epub 2025 Mar 30.
4
The Future of Medicine: How 3D Printing Is Transforming Pharmaceuticals.医学的未来：3D打印如何改变制药行业。
Pharmaceutics. 2025 Mar 19;17(3):390. doi: 10.3390/pharmaceutics17030390.
5
Novel Soft Dosage Forms for Paediatric Applications: Can We 3D-Print Them or Not?用于儿科应用的新型软剂型：我们能否进行3D打印？
Gels. 2025 Mar 8;11(3):187. doi: 10.3390/gels11030187.
重点介绍立体光刻3D打印在制药和医疗应用中的增材制造技术综述。
Int J Pharm X. 2023 Jan 3;5:100159. doi: 10.1016/j.ijpx.2023.100159. eCollection 2023 Dec.
4
Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug absorption of a poorly water-soluble drug.将脂质给药系统与无定形固体分散体相结合以提高难溶性药物的口服吸收。
J Control Release. 2022 Sep;349:206-212. doi: 10.1016/j.jconrel.2022.06.057. Epub 2022 Jul 8.
5
A comprehensive review of recent developments in 3D printing technique for ceramic membrane fabrication for water purification.用于水净化的陶瓷膜制造3D打印技术最新进展的全面综述。
RSC Adv. 2019 May 29;9(29):16869-16883. doi: 10.1039/c9ra00872a. eCollection 2019 May 24.
6
Selective Laser Sintering (SLS), a New Chapter in the Production of Solid Oral Forms (SOFs) by 3D Printing.选择性激光烧结（SLS），3D打印固体口服制剂（SOFs）生产的新篇章。
Pharmaceutics. 2021 Aug 6;13(8):1212. doi: 10.3390/pharmaceutics13081212.
7
Advances in powder bed fusion 3D printing in drug delivery and healthcare.粉末床融合 3D 打印在药物输送和医疗保健方面的进展。
Adv Drug Deliv Rev. 2021 Jul;174:406-424. doi: 10.1016/j.addr.2021.04.025. Epub 2021 May 2.
8
Emerging 3D printing technologies for drug delivery devices: Current status and future perspective.新兴的 3D 打印给药装置技术：现状与未来展望。
Adv Drug Deliv Rev. 2021 Jul;174:294-316. doi: 10.1016/j.addr.2021.04.019. Epub 2021 Apr 23.
9
Surface Modification of 3D Printed Polycaprolactone Constructs via a Solvent Treatment: Impact on Physical and Osteogenic Properties.通过溶剂处理对3D打印聚己内酯结构进行表面改性：对物理和骨生成特性的影响。
ACS Biomater Sci Eng. 2019 Jan 14;5(1):318-328. doi: 10.1021/acsbiomaterials.8b01018. Epub 2018 Dec 10.
10
Fabrication and Evaluation of 3D Printed Poly(l-lactide) Scaffold Functionalized with Quercetin-Polydopamine for Bone Tissue Engineering.用于骨组织工程的槲皮素-聚多巴胺功能化3D打印聚（L-丙交酯）支架的制备与评价
ACS Biomater Sci Eng. 2019 May 13;5(5):2506-2518. doi: 10.1021/acsbiomaterials.9b00254. Epub 2019 May 2.