Martel Véronique, Filhol Odile, Nueda Arsenio, Cochet Claude
INSERM EMI 104, Département de Biologie Moléculaire et Structurale, CEA, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
Ann N Y Acad Sci. 2002 Nov;973:272-7. doi: 10.1111/j.1749-6632.2002.tb04648.x.
Accumulating evidence indicates that in addition to the classical complex, the catalytic and regulatory subunits of CK2 can also exist as free populations in living cells. The association of recombinant CK2 subunits in vitro has been characterized, providing evidence for the first time for their targeted interactions in living cells. The data also suggest that the regulation by phosphorylation of many CK2 substrates may strongly depend on the dynamic localization/association of its subunits.
越来越多的证据表明，除了经典复合物外，CK2的催化亚基和调节亚基在活细胞中也可以以游离形式存在。已经对重组CK2亚基在体外的结合进行了表征，首次为它们在活细胞中的靶向相互作用提供了证据。数据还表明，许多CK2底物的磷酸化调节可能强烈依赖于其亚基的动态定位/结合。
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