Fujino Kiyohiro, Oertel Donata
Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison 53706, USA.
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):265-70. doi: 10.1073/pnas.0135345100. Epub 2002 Dec 16.
The dorsal cochlear nucleus integrates acoustic with multimodal sensory inputs from widespread areas of the brain. Multimodal inputs are brought to spiny dendrites of fusiform and cartwheel cells in the molecular layer by parallel fibers through synapses that are subject to long-term potentiation and long-term depression. Acoustic cues are brought to smooth dendrites of fusiform cells in the deep layer by auditory nerve fibers through synapses that do not show plasticity. Plasticity requires Ca(2+)-induced Ca(2+) release; its sensitivity to antagonists of N-methyl-d-aspartate and metabotropic glutamate receptors differs in fusiform and cartwheel cells.
背侧耳蜗核将听觉与来自大脑广泛区域的多模态感觉输入进行整合。多模态输入通过平行纤维经突触传递至分子层中梭形细胞和车轮状细胞的棘状树突，这些突触可发生长时程增强和长时程抑制。听觉线索由听神经纤维经不显示可塑性的突触传递至深层梭形细胞的平滑树突。可塑性需要钙诱导的钙释放；其对N-甲基-D-天冬氨酸和代谢型谷氨酸受体拮抗剂的敏感性在梭形细胞和车轮状细胞中有所不同。
