Stachs Oliver, Martin Heiner, Kirchhoff Alexander, Stave Joachim, Terwee Thom, Guthoff Rudolf
Department of Ophthalmology, University of Rostock, Doberaner Strasse 140, 18055 Rostock, Germany.
Graefes Arch Clin Exp Ophthalmol. 2002 Nov;240(11):906-12. doi: 10.1007/s00417-002-0551-2. Epub 2002 Oct 9.
Our objective was to develop a three-dimensional high-resolution ultrasonic imaging technique to be utilized for in-vivo characterization of the ciliary body and the posterior iris. The benefit of this imaging in enhancing the quantification of the configurational changes in the ciliary body during accommodation is demonstrated.
Sequential ultrasound biomicroscopic images of the ciliary body region were obtained with a computer-controlled scanning device designed for use with a standard ultrasound biomicroscope for 3D imaging. Custom-made software allows online data collection, data analysis and 3D reconstruction in conjunction with commercially available VoxelView software.
The three-dimensional presentation allows a close approximation of the ciliary muscle inside the ciliary body in vivo. We are able to distinguish and to analyze the changes in the muscle contour in different accommodation states. During accommodation a shift in the ciliary muscle center of gravity in a range of 0.04-0.26 mm (mean 0.13+/-0.06 mm) in the direction of the lens equator, with an interindividual variation and a small decrease with age, was observed.
High-resolution ultrasound is a well established technique for in-vivo investigation of the anterior segment. Three-dimensional ultrasound biomicroscopy allows an assessment of the individual ciliary muscle activity in consideration of the ciliary processes. In combination with a contour analysis tool we improved the muscle contour determination during different accommodation states. The investigation showed an activity of the ciliary muscle in young volunteers as well as those of presbyopic age.
我们的目标是开发一种三维高分辨率超声成像技术，用于睫状体和虹膜后部的体内特征分析。本文展示了这种成像技术在增强调节过程中睫状体形态变化量化方面的优势。
使用专为三维成像设计的计算机控制扫描设备，与标准超声生物显微镜配合，获取睫状体区域的连续超声生物显微镜图像。定制软件结合市售的VoxelView软件，可进行在线数据采集、数据分析和三维重建。
三维呈现能够在体内对睫状体内的睫状肌进行精确模拟。我们能够区分并分析不同调节状态下肌肉轮廓的变化。在调节过程中，观察到睫状肌重心向晶状体赤道方向移动，移动范围为0.04 - 0.26毫米（平均0.13±0.06毫米），个体间存在差异，且随年龄略有下降。
高分辨率超声是一种成熟的眼前节体内研究技术。三维超声生物显微镜能够在考虑睫状突的情况下评估个体睫状肌活动。结合轮廓分析工具，我们在不同调节状态下改进了肌肉轮廓的确定。研究显示年轻志愿者以及老花眼患者的睫状肌均有活动。
