Kotenko Sergei V
Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry, 185 South Orange Avenue, MSB E-631, Newark, NJ 07103, USA.
Cytokine Growth Factor Rev. 2002 Jun;13(3):223-40. doi: 10.1016/s1359-6101(02)00012-6.
Five novel cytokines (IL-19, IL-20, IL-22 (IL-TIF), IL-24 (human MDA-7, mouse FISP, rat C49A/Mob-5), and IL-26 (AK155)) demonstrating limited primary sequence identity and probable structural homology to IL-10 have been identified. These cellular cytokines, as well as several cytokines encoded in viral genomes (viral cytokines), form a family of IL-10-related cytokines or the IL-10 family. These cytokines share not only homology but also receptor subunits and perhaps activities. Receptors for these cytokines belong to the class II cytokine receptor family. The receptors are IL-10R2 (CRF2-4), IL-22R1 (CRF2-9), IL-22BP (CRF2-10), IL-20R1 (CRF2-8) and IL-20R2 (CRF2-11). Biological activities of these cytokines, receptor utilization and signaling, as well as expression patterns for cytokines and their receptors are summarized. Although data indicate that these cytokines are involved in regulation of inflammatory and immune responses, their major functions remain to be discovered.
已鉴定出五种新型细胞因子（白细胞介素-19、白细胞介素-20、白细胞介素-22（白细胞介素-TIF）、白细胞介素-24（人黑素瘤分化相关基因-7、小鼠FISP、大鼠C49A/Mob-5）和白细胞介素-26（AK155）），它们与白细胞介素-10的一级序列同源性有限，但可能具有结构同源性。这些细胞因子以及病毒基因组中编码的几种细胞因子（病毒细胞因子），构成了白细胞介素-10相关细胞因子家族或白细胞介素-10家族。这些细胞因子不仅具有同源性，还共享受体亚基，甚至可能具有相似的活性。这些细胞因子的受体属于II类细胞因子受体家族。这些受体包括白细胞介素-10R2（CRF2-4）、白细胞介素-22R1（CRF2-9）、白细胞介素-22结合蛋白（CRF2-10）、白细胞介素-20R1（CRF2-8）和白细胞介素-20R2（CRF2-11）。本文总结了这些细胞因子的生物学活性、受体利用和信号传导，以及细胞因子及其受体的表达模式。尽管数据表明这些细胞因子参与炎症和免疫反应的调节，但其主要功能仍有待发现。
