Miki Keisuke, Miki Mari, Okano Yoshio, Nakamura Yoichi, Ogushi Fumitaka, Ohtsuki Yuji, Nakayama Takuro
Department of Internal Medicine, JA Kochi Hospital, Nankoku, Kochi.
Intern Med. 2002 Nov;41(11):993-6. doi: 10.2169/internalmedicine.41.993.
Smoking causes various changes in the lung. This report describes a case of cigarette smoke-induced acute eosinophilic pneumonia (CS-AEP) with neutrophilia in the blood. However, the precise mechanism is unknown, so we examined the effect of exposure to cigarette smoke extracts on the production of interleukin (IL)-4, IL-5, IL-8, IL-18, granulocyte macrophage-colony stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) by human bronchial epithelial cells (HBECs) obtained from the patient. We found that IL-8 released from HBECs was involved in neutrophilia in the blood, and is a new factor in the development of AEP, especially in the early phase.
吸烟会导致肺部发生各种变化。本报告描述了一例香烟烟雾诱导的急性嗜酸性粒细胞性肺炎（CS-AEP）病例，该病例血液中存在中性粒细胞增多。然而，确切机制尚不清楚，因此我们检测了香烟烟雾提取物对从该患者获取的人支气管上皮细胞（HBECs）产生白细胞介素（IL）-4、IL-5、IL-8、IL-18、粒细胞巨噬细胞集落刺激因子（GM-CSF）和血管内皮生长因子（VEGF）的影响。我们发现，HBECs释放的IL-8与血液中的中性粒细胞增多有关，并且是AEP发生发展的一个新因素，尤其是在早期阶段。
