Etiz Durmuş, Orhan Bülent, Demirüstü Canan, Ozdamar Kazim, Cakmak Ahmet
Osmangazi University Faculty of Medicine, Department of Radiation Oncology, Eskişehir, Turkey.
Tumori. 2002 Sep-Oct;88(5):379-84. doi: 10.1177/030089160208800506.
A number of oral toxicity scoring systems have been described, but their direct comparison has rarely been undertaken and little data exists. An impediment to mucositis research has been the lack of an accepted, validated scoring system. The objective of this study was to design a test and validation of scoring systems.
Forty-three patients with head and neck malignancies who had been irradiated were evaluated. Five different mucositis scoring systems (World Health Organization, Radiation Therapy Oncology Group, "Hickey", "Van der Schueren" and "Makkonen") were compared with each other.
Daily mucositis scores demonstrated a high correlation among scoring systems (P < 0.05 and coefficient of correlation kappa and r = 0.5-0.95). Objective mucositis scores demonstrated a strong correlation with symptoms.
All scoring systems were equally valid. The exact grading of mucositis is achieved by combining clinical information about pain and nutritional status with oral mucosal reactions.
已经描述了多种口腔毒性评分系统，但很少对它们进行直接比较，相关数据也很少。口腔黏膜炎研究的一个障碍是缺乏一个被认可、经过验证的评分系统。本研究的目的是设计并验证评分系统。
对43例接受过放疗的头颈部恶性肿瘤患者进行了评估。比较了五种不同的口腔黏膜炎评分系统（世界卫生组织、放射治疗肿瘤学组、“希基”、“范德舒伦”和“马科宁”）。
每日口腔黏膜炎评分在各评分系统之间显示出高度相关性（P < 0.05，相关系数kappa和r = 0.5 - 0.95）。客观的口腔黏膜炎评分与症状显示出强烈相关性。
所有评分系统同样有效。通过将关于疼痛和营养状况的临床信息与口腔黏膜反应相结合，可以实现口腔黏膜炎的准确分级。
