Brummond Kay M, Chen Hongfeng, Sill Peter, You Lingfeng
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
J Am Chem Soc. 2002 Dec 25;124(51):15186-7. doi: 10.1021/ja027588p.
A rhodium(I)-catalyzed allenic Alder ene reaction to prepare cross-conjugated trienes has been discovered. The scope and limitations are currently being investigated, and the results obtained to date are reported on. This method shows enticing functional group compatibility by tolerating terminal and internal alkynes, hydroxyl, sulfonamide, ether, and diester groups. Progress has been made to increase the stereoselectivity of the olefinic side chain via an unprecendented iridium(I) catalyzed Alder-ene reaction.
已发现一种铑（I）催化的联烯型Alder-烯反应来制备交叉共轭三烯。目前正在研究其适用范围和局限性，并报告了迄今为止所获得的结果。该方法通过耐受末端和内炔、羟基、磺酰胺、醚和二酯基团，显示出诱人的官能团兼容性。通过前所未有的铱（I）催化的Alder-烯反应提高烯烃侧链的立体选择性方面已取得进展。
