用于立体选择性合成取代1,4 - 二烯和交叉共轭三烯的丙二烯 - 炔烃交叉偶联反应
Allene-alkyne cross-coupling for stereoselective synthesis of substituted 1,4-dienes and cross-conjugated trienes.
作者信息
Shimp Heidi L, Hare Alissa, McLaughlin Martin, Micalizio Glenn C
机构信息
Department of Chemistry, Yale Univeristy, New Haven, Connecticut 06520-8107.
出版信息
Tetrahedron. 2008 Apr 14;64(4):3437-3445. doi: 10.1016/j.tet.2008.02.015.
Abstract
Titanium-mediated cross-coupling of allenic alcohols with alkynes has been investigated. Divergent reaction pathways were discovered that provide either stereodefined 1,4-dienes or substituted cross-conjugated trienes. In short, allene substitution plays a critical role in the determination of reaction pathway.
摘要
已对钛介导的联烯醇与炔烃的交叉偶联反应进行了研究。发现了不同的反应途径，这些途径可提供立体定向的1,4 - 二烯或取代的交叉共轭三烯。简而言之，联烯取代在反应途径的确定中起着关键作用。
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