Hui Ying, Wu Yiyong, Xiao Luyan, Tang Zhiyi, Wu Yuli, Li Yanchun
Department of Obstetrics and Gynecology, Beijing Hospital, Ministry of Public Health, Beijing 100730, China.
Zhonghua Fu Chan Ke Za Zhi. 2002 Oct;37(10):598-600.
To observe the effects of hormone replacement therapy (HRT) on fasting total plasma homocysteine levels and echocardiography in postmenopausal women.
Subjects were assigned to four groups. Group I: 30 postmenopausal women were assigned to sequentially combined daily 0.625 mg conjugated equine estrogen (CEE) plus 2 mg medroxyprogesterone acetate (MPA) or plus 4 mg MPA daily for 14 days in a 28 day cycle for 3 months. Group II: 30 postmenopausal women did not received HRT. Group III: 20 postmenopausal women who took HRT for 1.5 years. Group IV: 20 postmenopausal women who never took HRT. Measurement of fasting total plasma homocysteine was performed before and after 3 months treatment in group I and group II. Fasting total plasma homocysteine was determined and echocardiography was taken in group III and group IV.
Fasting total plasma homocysteine concentrations were not altered significantly after 3 months in group I and group II [before HRT: (9.3 +/- 2.5) micro mol/L, (9.4 +/- 2.9) micro mol/L; after HRT: (9.1 +/- 2.8) micro mol/L, (9.8 +/- 3.6) micro mol/L, respectively (P > 0.05)]. Compared with women of group III, women of group IV had statistically significant lower plasma homocysteine [(8.0 +/- 1.3) micro mol/L, (10.3 +/- 3.2) micro mol/L, respectively (P < 0.05)]. Echocardiography was not found any difference between those two groups.
Three months HRT has no effect on plasma homocysteine levels in postmenopausal women but the postmenopausal women using HRT 1.5 years have lower plasma homocysteine levels than those who never received HRT. Echocardiography showed no detectable changes between women received 1.5 years HRT and those who received no HRT.
观察激素替代疗法（HRT）对绝经后女性空腹血浆总同型半胱氨酸水平及超声心动图的影响。
将受试者分为四组。第一组：30名绝经后女性，在28天周期内，连续14天每日依次联合服用0.625mg共轭马雌激素（CEE）加2mg醋酸甲羟孕酮（MPA）或加4mg MPA，共3个月。第二组：30名绝经后女性未接受HRT。第三组：20名接受HRT 1.5年的绝经后女性。第四组：20名从未接受HRT的绝经后女性。第一组和第二组在治疗3个月前后测量空腹血浆总同型半胱氨酸。第三组和第四组测定空腹血浆总同型半胱氨酸并进行超声心动图检查。
第一组和第二组在3个月后空腹血浆总同型半胱氨酸浓度无显著变化[HRT前：（9.3±2.5）μmol/L，（9.4±2.9）μmol/L；HRT后：（9.1±2.8）μmol/L，（9.8±3.6）μmol/L，分别（P>0.05）]。与第三组女性相比，第四组女性的血浆同型半胱氨酸在统计学上显著更低[分别为（8.0±1.3）μmol/L，（10.3±3.2）μmol/L，（P<0.05）]。两组之间超声心动图未发现差异。
3个月的HRT对绝经后女性血浆同型半胱氨酸水平无影响，但接受HRT 1.5年的绝经后女性血浆同型半胱氨酸水平低于从未接受HRT的女性。超声心动图显示接受1.5年HRT的女性与未接受HRT的女性之间未检测到变化。
