两名4p三体综合征患者母亲的4号染色体着丝粒分裂。
Centric fission of chromosome no. 4 in the mother of two patients with trisomy 4p.
作者信息
Dallapiccola B, Mastroiacovo P, Gandini E
出版信息
Hum Genet. 1976 Jan 28;31(1):121-5. doi: 10.1007/BF00270409.
PMID:1248819
Abstract
Centric fission of chromosome No. 4 was found in the healthy mother of two children with trisomy 4p. The two telocentrics derived are stable and show no evidence of fusing again. The 2:3 ratio of unbalanced offsprings born to the proposita indicates that, contrary to the evidence emerging from studies in other species, the risk for the production of unbalanced gametes is high.
摘要
在两名患有4p三体综合征儿童的健康母亲体内发现了4号染色体的着丝粒分裂。由此产生的两条端着丝粒染色体是稳定的，没有再次融合的迹象。先证者生育的不平衡后代中2:3的比例表明，与其他物种研究得出的证据相反，产生不平衡配子的风险很高。
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