Davis C P, Savage D C
Infect Immun. 1976 Jan;13(1):180-8. doi: 10.1128/iai.13.1.180-188.1976.
Indigenous segmented filamentous microbes attach to murine ileal epithelial cells. These microbes can be seen on the epithelial surface with a scanning electron microscope. They colonize preferentially the distal ileum in mice. Penicillin, placed in the animal's drinking water, eliminates the microbes from the mouse ileum, but recolinization of the ileum is observed 4 to 5 weeks after the penicillin treatment is stopped. Within 3 to 5 h after rats are given penicillin, the morphology of the microbes is changed. Their external surfaces are wrinkled or broken. Vacated and partially vacated attachment sites are observed. Almost all of the organisms disappear from murine ilea after the animals are exposed to penicillin for 10 h. These observations are discussed in relation to the microbe itself and in its interaction with ileal epithelial cells.
本土分段丝状微生物附着于小鼠回肠上皮细胞。用扫描电子显微镜可在上皮表面看到这些微生物。它们优先定殖于小鼠的回肠远端。置于动物饮用水中的青霉素可从小鼠回肠清除这些微生物，但在青霉素治疗停止后4至5周可观察到回肠的重新定殖。给大鼠注射青霉素后3至5小时内，微生物的形态发生改变。它们的外表面出现褶皱或破损。观察到有空出和部分空出的附着位点。动物暴露于青霉素10小时后，几乎所有微生物从小鼠回肠消失。针对这些观察结果，从微生物本身及其与回肠上皮细胞的相互作用方面进行了讨论。
