Hajnal Andras, Norgren Ralph
Department of Behavioral Science, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.
Neuroreport. 2002 Dec 3;13(17):2213-6. doi: 10.1097/00001756-200212030-00010.
Dopamine in the nucleus accumbens has been implicated in motivated behavior, including feeding. Normal feeding occurs in patterns, but little is known about how these schedules influence this neural system. We hypothesized that repeated access to preferred foods would augment dopamine clearance. Rats on a restricted feeding schedule had access to 0.3 M sucrose or water followed 2 h later by chow. The rats were kept on this regimen for 7 days, with microdialysis performed on the last day. During the chow period, dopamine turnover in the nucleus accumbens was higher when preceded by sucrose than by water. This finding suggests that, under some dietary conditions, neuroadaptation occurs in response to feeding and these changes may, in turn, influence future meals.
伏隔核中的多巴胺与包括进食在内的动机行为有关。正常进食呈一定模式，但对于这些模式如何影响该神经系统却知之甚少。我们推测，反复接触偏好的食物会增加多巴胺清除率。按限制进食时间表喂养的大鼠可获取0.3M蔗糖或水，2小时后再给予食物。大鼠按此方案饲养7天，最后一天进行微透析。在进食期间，伏隔核中的多巴胺周转率在蔗糖摄入后高于水摄入后。这一发现表明，在某些饮食条件下，会发生针对进食的神经适应性变化，而这些变化反过来可能会影响未来的进食。
