Chan N N, Chan J C N
Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Diabetologia. 2002 Dec;45(12):1609-16. doi: 10.1007/s00125-002-0975-6. Epub 2002 Oct 30.
Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) diabetes mellitus. Nitric oxide is synthesised by nitric oxide synthase. Asymmetric dimethylarginine is a major endogenous nitric oxide synthase inhibitor. Increased circulating asymmetric dimethylarginine was initially found in patients with chronic renal failure and subsequently many other disease states. Increased asymmetric dimethylarginine plasma concentrations could contribute to the development of insulin resistance and coronary heart disease. Understanding of the pathophysiological role of asymmetric dimethylarginine could lead to novel therapies in the prevention of arteriosclerosis and coronary heart disease.
内皮衍生的一氧化氮在血管张力调节和血管稳态维持中起主要作用。一氧化氮生物合成受损和生物利用度降低所导致的内皮功能障碍与胰岛素抵抗综合征及II型（非胰岛素依赖型）糖尿病有关。一氧化氮由一氧化氮合酶合成。不对称二甲基精氨酸是一种主要的内源性一氧化氮合酶抑制剂。循环中不对称二甲基精氨酸水平升高最初在慢性肾衰竭患者中被发现，随后在许多其他疾病状态中也有发现。不对称二甲基精氨酸血浆浓度升高可能会导致胰岛素抵抗和冠心病的发生。了解不对称二甲基精氨酸的病理生理作用可能会带来预防动脉硬化和冠心病的新疗法。
