多囊卵巢综合征患者饮食植物化学物质指数与代谢指标、血清不对称二甲基精氨酸及致动脉粥样硬化指数的关联

Association of dietary phytochemical index with metabolic markers, serum asymmetric dimethylarginine and atherogenic indices in patients with polycystic ovary syndrome.

作者信息

Amirkhizi Farshad, Taghizadeh Mahdiyeh, Hamedi-Shahraki Soudabeh, Asghari Somayyeh

机构信息

Department of Nutrition, School of Public Health, Zabol University of Medical Sciences, Zabol, Iran.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No#44, Hojjatdoust St., Naderi St., Keshavarz Blvd, Tehran, 141556117, Iran.

出版信息

Nutr Metab (Lond). 2025 May 7;22(1):39. doi: 10.1186/s12986-025-00932-1.

DOI:10.1186/s12986-025-00932-1

PMID:40336098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12060492/

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular diseases (CVD). Plant-based diets are associated with reduced CVD risk factors. This study aimed to explore the associations between dietary phytochemical index (DPI) and asymmetric dimethylarginine (ADMA), lipid profile, atherogenic indices, and other metabolic biomarkers in women with PCOS.

METHODS

In this cross-sectional study, 150 females aged 18-45 years diagnosed with PCOS were recruited. An interviewer-administered questionnaire was applied to gather the relevant demographic characteristics, detailed clinical information, and lifestyle habits of participants. A validated semi-quantitative food frequency questionnaire was used to assess dietary intake, and DPI was calculated accordingly. We used multiple linear regression to determine the association between serum concentrations of ADMA, total testosterone, sex hormone-binding globulin (SHBG), fasting serum glucose (FSG), insulin, and lipid profile, as well as atherogenic indices across quartiles of DPI.

RESULTS

There was a negative correlation between the DPI and serum levels of ADMA (p-trend = 0.022), triglycerides (TG) (p-trend = 0.003), oxidized low-density lipoprotein cholesterol (ox-LDL) (p-trend = 0.001), insulin (p-trend = 0.045) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p-trend = 0.018). Moreover, there was a tendency for visceral adiposity index (VAI) (p-trend = 0.005) and atherogenic index of plasma (AIP) (p-trend = 0.001) to decrease as the quartile categories of DPI increased. No significant regular trend was found for serum levels of FSG, SHBG, total testosterone, other lipid profiles, and lipid accumulation product (LAP).

CONCLUSIONS

These findings suggest that adherence to a phytochemical-rich diet decrease the CVD risk factors in PCOS patients.

摘要

背景

多囊卵巢综合征（PCOS）与心血管疾病（CVD）风险增加相关。植物性饮食与降低CVD风险因素有关。本研究旨在探讨多囊卵巢综合征女性的膳食植物化学物指数（DPI）与不对称二甲基精氨酸（ADMA）、血脂谱、致动脉粥样硬化指数及其他代谢生物标志物之间的关联。

方法

在这项横断面研究中，招募了150名年龄在18 - 45岁被诊断为PCOS的女性。采用访谈式问卷收集参与者的相关人口统计学特征、详细临床信息和生活方式习惯。使用经过验证的半定量食物频率问卷评估膳食摄入量，并据此计算DPI。我们使用多元线性回归来确定ADMA、总睾酮、性激素结合球蛋白（SHBG）、空腹血糖（FSG）、胰岛素的血清浓度与血脂谱以及DPI四分位数间的致动脉粥样硬化指数之间的关联。

结果

DPI与ADMA（p趋势 = 0.022）、甘油三酯（TG）（p趋势 = 0.003）、氧化型低密度脂蛋白胆固醇（ox - LDL）（p趋势 = 0.001）、胰岛素（p趋势 = 0.045）以及胰岛素抵抗稳态模型评估（HOMA - IR）（p趋势 = 0.018）的血清水平呈负相关。此外，随着DPI四分位数类别增加，内脏脂肪指数（VAI）（p趋势 = 0.005）和血浆致动脉粥样硬化指数（AIP）（p趋势 = 0.001）有下降趋势。FSG、SHBG、总睾酮、其他血脂谱以及脂质蓄积产物（LAP）的血清水平未发现显著的规律趋势。