正常体重和肥胖慢性肾脏病血液透析患者血清不对称二甲基精氨酸浓度。

Asymmetric dimethylarginine serum concentration in normal weight and obese CKD patients treated with hemodialysis.

机构信息

Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No#44, Hojjatdoost St., Naderi St., Keshavarz Blvd, Tehran, Iran.

出版信息

BMC Nephrol. 2024 Sep 5;25(1):294. doi: 10.1186/s12882-024-03736-2.

DOI:10.1186/s12882-024-03736-2

PMID:39237885

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11378466/

Abstract

INTRODUCTION

Asymmetric dimethylarginine (ADMA), a cardiovascular risk factor, increases in renal failure. The aim of this study was to investigate ADMA levels in normal weight and obese patients on hemodialysis.

METHODS

In this cross-sectional study, 43 normal weight and 43 obese patients on regular hemodialysis were examined. Malnutrition-inflammation score (MIS), anthropometry, circulating ADMA, lipid profiles including triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and lipid ratios, glucose homeostasis parameters, blood pressure, and high-sensitivity C-reactive protein (hs-CRP) were assessed.

RESULTS

Serum levels of ADMA were significantly lower in the obese compared to the normal weight patients (10268.2 ± 10092.4 vs. 13765.2 ± 9951.3 ng/l, P = 0.03). At the same time MIS score (6.1 ± 2.4 vs. 10.7 ± 3.2, P < 0.001), systolic blood pressure (119 ± 26.8 vs. 134.2 ± 24.7 mmHg, P = 0.018) and mean arterial pressure (91.3 ± 18.6 vs. 100.9 ± 15.9 mmHg, P = 0.028) were significantly lower in the obese than the normal weight group. Fasting blood glucose (P = 0.045), TG/HDL (P = 0.03), TC/HDL (P = 0.019), and LDL/HDL (P = 0.005) ratios, and hs-CRP (P = 0.015) levels were significantly higher in the obese than in the normal weight group.

CONCLUSION

Circulating ADMA was significantly lower in obese than in normal weight patients on hemodialysis, which was concomitant with lower MIS, indicating a better nutritional inflammatory status, and lower blood pressure.

摘要

简介

不对称二甲基精氨酸（ADMA）是心血管疾病的一个风险因素，在肾衰竭中会增加。本研究的目的是调查在接受常规血液透析的正常体重和肥胖患者中的 ADMA 水平。

方法

在这项横断面研究中，检查了 43 名正常体重和 43 名肥胖的接受常规血液透析的患者。评估了营养不良-炎症评分（MIS）、人体测量学、循环 ADMA、包括甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和脂质比值的血脂谱、葡萄糖稳态参数、血压和高敏 C 反应蛋白（hs-CRP）。

结果

与正常体重患者相比，肥胖患者的血清 ADMA 水平显著降低（10268.2±10091.3 vs. 13765.2±9951.3 ng/l，P=0.03）。与此同时，MIS 评分（6.1±2.4 vs. 10.7±3.2，P<0.001）、收缩压（119±26.8 vs. 134.2±24.7 mmHg，P=0.018）和平均动脉压（91.3±18.6 vs. 100.9±15.9 mmHg，P=0.028）在肥胖患者中明显低于正常体重组。空腹血糖（P=0.045）、TG/HDL（P=0.03）、TC/HDL（P=0.019）和 LDL/HDL（P=0.005）比值以及 hs-CRP（P=0.015）水平在肥胖患者中明显高于正常体重组。