Damião Renata, Castro Teresa G, Cardoso Marly A, Gimeno Suely G A, Ferreira Sandra R G
Department of Internal Medicine, Division of Endocrinology, Federal University of São Paulo, São Paulo, Brazil.
Br J Nutr. 2006 Sep;96(3):532-8.
The present study examined the association between dietary factors and metabolic syndrome in a 7-year follow-up of Japanese-Brazilians. In 1993, a survey estimated the prevalence of diabetes in a Japanese-Brazilian population aged 40-79 years. From 647 subjects studied at baseline, 394 (60.9 %) participated in a second survey (2000); after exclusion of subjects with self-reported diseases, 23.4 % (n 151) were included in the present analysis. Metabolic syndrome diagnosis was based on the National Cholesterol Education Program criteria modified for Asians. Food intake was assessed by a validated food-frequency questionnaire. At baseline, mean ages were 56.1 (sd 9.7) and 54.7 (sd 10.6) years for men and women, respectively. Similar cumulative incidence rates of the metabolic syndrome were found in both sexes (36.9 (95 % CI 26.6, 48.1)% for men and 38.8 (95 % CI 27.1, 51.4) % for women). In 1993, mean values of blood pressure, waist circumference for men and 2 h plasma glucose for both sexes were higher among subjects who developed metabolic syndrome when compared with those who did not. Comparisons of nutrient intakes between subsets of subjects who developed or did not develop metabolic syndrome showed an association of protein intake with the syndrome only in men (96.4 (sd 56.8) v. 74.3 (sd 26.0) g/d; P<0.05). Odds ratios of the metabolic syndrome across tertiles of food groups intake showed that among men the highest tertile of red meat consumption was associated with a 4.7-fold increase in risk of developing the syndrome, after adjustments for confounders. However, the statistical significance of this model disappeared when saturated fatty acids were added. The data raised the possibility of a role of red meat consumption for the occurrence of metabolic syndrome in Japanese-Brazilian men. The present findings may have implications for the prevention of metabolic syndrome in this high-risk population.
本研究在对日本裔巴西人进行的7年随访中，考察了饮食因素与代谢综合征之间的关联。1993年，一项调查估计了40 - 79岁日本裔巴西人群中的糖尿病患病率。在基线研究的647名受试者中，394名（60.9%）参与了第二次调查（2000年）；在排除自我报告患有疾病的受试者后，23.4%（n = 151）纳入本分析。代谢综合征的诊断基于针对亚洲人修改后的美国国家胆固醇教育计划标准。食物摄入量通过一份经验证有效的食物频率问卷进行评估。在基线时，男性和女性的平均年龄分别为56.1（标准差9.7）岁和54.7（标准差10.6）岁。在两性中发现代谢综合征的累积发病率相似（男性为36.9（95%置信区间26.6, 48.1）%，女性为38.8（95%置信区间27.1, 51.4）%）。1993年，与未患代谢综合征的受试者相比，患代谢综合征的受试者的血压、男性腰围以及两性的2小时血浆葡萄糖均值更高。对患或未患代谢综合征的受试者亚组之间的营养素摄入量进行比较显示，仅在男性中蛋白质摄入量与该综合征有关联（96.4（标准差56.8）对74.3（标准差26.0）克/天；P<0.05）。按食物组摄入量三分位数划分的代谢综合征比值比显示，在对混杂因素进行调整后，男性中红肉消费最高三分位数与患该综合征风险增加4.7倍相关。然而，当加入饱和脂肪酸后，该模型的统计学显著性消失。这些数据提示了红肉消费在日本裔巴西男性代谢综合征发生中可能起作用。本研究结果可能对该高危人群代谢综合征的预防具有启示意义。
