Khayyal Mohamed T, el-Ghazaly Mona A, Abdallah Dalal M, Nassar Noha N, Okpanyi Samuel N, Kreuter Matthias-Heinrich
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Arzneimittelforschung. 2002;52(11):797-802. doi: 10.1055/s-0031-1299970.
A specially prepared olive leaf extract (EFLA 943) has been tested for its blood pressure lowering activity in rats rendered hypertensive by daily oral doses of L-NAME (NG-nitro-L-arginine methyl ester, 50 mg/kg) for at least 4 weeks. Oral administration of the extract at different dose levels at the same time as L-NAME for a period of 8 weeks showed a dose dependent prophylactic effect against the rise in blood pressure induced by L-NAME, best effects being induced by a dose of 100 mg/kg of the extract. In rats previously rendered hypertensive by L-NAME for 6 weeks and then treated with that dose of the extract for a further 6 weeks without discontinuation of L-NAME, normalisation of the blood pressure was observed. The findings confirm previous reports on the hypotensive effects of olive leaf. The special extract, EFLA 943, was shown to give consistent results with little individual variability. The antihypertensive effect of the extract may be related to a variety of factors involving reversal of vascular changes involved in the L-NAME induced hypertension.
一种特制的橄榄叶提取物（EFLA 943）已在通过每日口服L-NAME（NG-硝基-L-精氨酸甲酯，50毫克/千克）至少4周而导致高血压的大鼠中进行了其降血压活性测试。在给予L-NAME的同时，以不同剂量水平口服该提取物8周，结果显示其对L-NAME诱导的血压升高具有剂量依赖性预防作用，其中100毫克/千克提取物剂量的效果最佳。在先前通过L-NAME诱导高血压6周，然后在不停止L-NAME的情况下再用该剂量提取物治疗6周的大鼠中，观察到血压恢复正常。这些发现证实了先前关于橄榄叶降压作用的报道。特制提取物EFLA 943显示出一致的结果，个体差异很小。该提取物的降压作用可能与多种因素有关，包括逆转L-NAME诱导的高血压所涉及的血管变化。
