Groot M J
RIKILT-DLO, DLO-State Institute for Quality Control of Agricultural Products, Wageningen, The Netherlands.
J Vet Med A Physiol Pathol Clin Med. 2002 Nov;49(9):466-9. doi: 10.1046/j.1439-0442.2002.00477.x.
Adult female beef cattle found positive for stanozolol in the urine were investigated for liver pathology. In all the animals toxic hepatitis was found, including cholestasis, periportal fibrosis and inflammation, focal necrosis and blood filled lacunae. As no clinical data of the cows were available, apart from the history of illegal stanozolol abuse, it is not possible to attribute all changes to the illegal hormone treatment. Moreover, the cows have probably been treated with a cocktail, and apart from stanozolol more anabolic steroids may have been used. Management factors, viral and bacterial infections, former caesarean sections and especially feeding regime may also be responsible for the lesions described. Striking similarities with data from hepatotoxicity found in human body builders using similar agents, however, suggest a major role of stanozolol as causative agent.
对尿液中司坦唑醇检测呈阳性的成年雌性肉牛进行了肝脏病理学调查。在所有动物中均发现了中毒性肝炎，包括胆汁淤积、汇管区周围纤维化和炎症、局灶性坏死以及充血腔隙。由于除了非法滥用司坦唑醇的病史外，没有这些母牛的临床数据，所以无法将所有变化都归因于非法激素治疗。此外，这些母牛可能接受了多种药物混合治疗，除司坦唑醇外，可能还使用了更多的合成代谢类固醇。管理因素、病毒和细菌感染、既往剖腹产手术，尤其是饲养方式也可能是所描述病变的原因。然而，与使用类似药物的人体健美运动员的肝毒性数据惊人相似，这表明司坦唑醇作为致病因素起主要作用。
