Pi-Sunyer F Xavier
Division of Endocrinology, Diabetes, and Nutrition, New York Obesity Research Center, Columbia University College of Physicians and Surgeons, St. Luke's-Roosevelt Hospital Center, New York 10025, USA.
Obes Res. 2002 Dec;10 Suppl 2:97S-104S. doi: 10.1038/oby.2002.202.
Obesity has reached epidemic proportions in the United States: more than 20% of adults are clinically obese as defined by a body mass index of 30 kg/m(2) or higher, and an additional 30% are overweight. Environmental, behavioral, and genetic factors have been shown to contribute to the development of obesity. Elevated body mass index, particularly caused by abdominal or upper-body obesity, has been associated with a number of diseases and metabolic abnormalities, many of which have high morbidity and mortality. These include hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, coronary heart disease, gallbladder disease, and certain malignancies. This underscores the importance of identifying people at risk for obesity and its related disease states.
超过20%的成年人根据体重指数达到30千克/平方米或更高的标准被临床诊断为肥胖，另有30%超重。环境、行为和遗传因素已被证明会导致肥胖的发生。体重指数升高，尤其是由腹部或上身肥胖引起的，与多种疾病和代谢异常有关，其中许多疾病具有高发病率和高死亡率。这些疾病包括高胰岛素血症、胰岛素抵抗、2型糖尿病、高血压、血脂异常、冠心病、胆囊疾病和某些恶性肿瘤。这凸显了识别肥胖及其相关疾病风险人群的重要性。
