气相色谱法测定片剂和栓剂中盐酸卡米芬的含量。
Gas-chromatographic determination of camylofine dihydrochloride in tablets and suppositories.
作者信息
Crombez E, van den Bossche W, De Moerloose P
出版信息
J Chromatogr. 1976 Feb 4;117(1):161-6. doi: 10.1016/s0021-9673(00)81077-8.
PMID:1249147
Abstract
A gas-chromatographic method for the quantitative determination of camylofine dihydrochloride, a spasmolytic agent, is described. The analysis is made on a porous polymer packing material, by determining the 3-methyl-1-butanol formed on alkaline hydrolysis of the drug. The method has been applied to the quantitative determination of the drug in two galenical forms, namely tablets and suppositories, in the presence of papaverine hydrochloride, codeine phosphate, novalgin and aminopyrine.
摘要
本文描述了一种用于定量测定解痉剂盐酸卡米芬的气相色谱法。该分析是在多孔聚合物填充材料上进行的，通过测定药物碱性水解生成的3-甲基-1-丁醇来进行。该方法已应用于在盐酸罂粟碱、磷酸可待因、安乃近和氨基比林存在的情况下，对两种制剂形式（即片剂和栓剂）中的药物进行定量测定。
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