Claydon N, Smith S, Stiller S, Newcombe R G, Addy M
Division of Restorative Dentistry, Dental School, Bristol, UK.
J Clin Periodontol. 2002 Dec;29(12):1072-7. doi: 10.1034/j.1600-051x.2002.291204.x.
Plaque inhibition by chlorhexidine (CHX) rinses is dose related with a relatively flat dose-response curve above 5-6 mg twice daily. Low dose regimens could therefore reduce local side effects but maintain reasonable efficacy.
To compare the plaque inhibitory properties of two low-dose CHX rinse products with more conventional levels delivered from proprietary rinses. A secondary outcome was a comparison with a stannous fluoride/amine fluoride (SFAF) rinse product.
The study was a five-treatments, negative controlled, randomised, single blind crossover design balanced for residual effects, involving 20 healthy subjects in a 24-h plaque re-growth model. On day 1 of each study period, subjects were rendered plaque free, suspended tooth cleaning and followed the appropriate rinse regimen. On day 2, subjects were scored for plaque by index and area. The rinse codes and rinsing regimens were: (A) 15 mg CHX 2 x daily for 30 s (0.1% CHX), (B) 9 mg CHX 2 x daily for 60 s (0.06% CHX), (C) 10 ml SFAF rinse 1 x daily for 30 s, (D) 15 ml placebo 2 x daily for 60 s, and (E) 6 mg CHX 2 x daily for 30 s (0.06% CHX).
Average mouth plaque indices and areas were highly significantly different between rinsing regimens. All test rinses were significantly more effective than the placebo rinse. There was a mean dose-response pattern for the CHX rinses, but there were no statistically significant differences between any of the test rinses.
Lower doses of chlorhexidine in rinses can be used to exert plaque inhibition comparable with products used at higher doses and equivalent to benchmark products such as the SFAF rinse. However, the availability of chlorhexidine from formulations has to be considered as in part explaining the results.
洗必泰（CHX）漱口水的防菌斑作用与剂量相关，每日两次使用5 - 6毫克以上时剂量反应曲线相对平缓。因此，低剂量方案可减少局部副作用，但保持合理疗效。
比较两种低剂量CHX漱口水产品与专利漱口水提供的更常规剂量的防菌斑特性。次要结果是与含氟亚锡/氟化胺（SFAF）漱口水产品进行比较。
该研究采用五组治疗、阴性对照、随机、单盲交叉设计，平衡残留效应，在24小时菌斑再生长模型中纳入20名健康受试者。在每个研究周期的第1天，使受试者口腔无菌斑，暂停牙齿清洁并遵循相应的漱口方案。在第2天，通过指数和面积对受试者的菌斑进行评分。漱口代码和漱口方案如下：（A）每日两次，每次15毫克CHX，持续30秒（0.1% CHX）；（B）每日两次，每次9毫克CHX，持续60秒（0.06% CHX）；（C）每日一次，每次10毫升SFAF漱口水，持续30秒；（D）每日两次，每次15毫升安慰剂，持续60秒；（E）每日两次，每次6毫克CHX，持续30秒（0.06% CHX）。
漱口方案之间的平均口腔菌斑指数和面积存在高度显著差异。所有测试漱口水均比安慰剂漱口水显著更有效。CHX漱口水存在平均剂量反应模式，但任何测试漱口水之间均无统计学显著差异。
较低剂量的洗必泰漱口水可用于发挥与高剂量产品相当的防菌斑作用，并等同于如SFAF漱口水等基准产品。然而，配方中洗必泰的可用性必须被视为部分解释这些结果的因素。
