含氯己定的三种漱口水对口腔微生物菌斑抗菌特性的比较：一项体外研究
Comparison of the Antibacterial Properties of Three Mouthwashes Containing Chlorhexidine Against Oral Microbial Plaques: An in vitro Study.
作者信息
Yousefimanesh Hojatollah, Amin Mansour, Robati Maryam, Goodarzi Hamed, Otoufi Masumeh
机构信息
Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Health Research Institute, Infectious and Tropical Diseases Research Center Ahvaz, Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
出版信息
Jundishapur J Microbiol. 2015 Feb 20;8(2):e17341. doi: 10.5812/jjm.17341. eCollection 2015 Feb.
BACKGROUND
The mouth provides an environment that allows the colonization and growth of a wide variety of microorganisms, especially bacteria. One of the most effective ways to reduce oral microorganisms is using mouthwashes.
OBJECTIVES
The aim of this study was to investigate the antibacterial effects of chlorhexidine mouthwashes (manufacture by Livar, Behsa, Boht) on common oral microorganisms.
MATERIALS AND METHODS
In this in vitro study, isolated colonies of four bacteria, including Streptococcus mutans, S. sanguinis, S. salivarius and Lactobacillus casei, were prepared for an antimicrobial mouth rinse test. The tube dilution method was used for determining the minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC).
RESULTS
The MICs for Kin gingival, Behsa and Boht mouthwashes were 0.14, 0.48 and 1000 micrograms/mL using the tube method for S. mutans, respectively. The MBCs for the mentioned mouthwashes were 0.23, 1.9 and 2000 micrograms/mL for S. mutans, respectively. The MICs for Kin gingival, Behsa and Boht mouthwashes were 0.073, 0.48 and 250 micrograms/mL using the tube method for S. sanguinis, respectively. The MBCs for the mentioned mouthwashes were 0.14, 1.9 and 1000 micrograms/mL for S. sanguinis, respectively.
CONCLUSIONS
The Kin Gingival chlorhexidine mouthwash has a greater effect than Behsa and Boht mouthwashes on oral microorganisms and is recommended to be used for plaque chemical inhibition.
背景
口腔提供了一个允许多种微生物，尤其是细菌定殖和生长的环境。减少口腔微生物最有效的方法之一是使用漱口水。
目的
本研究旨在调查氯己定漱口水（由利瓦尔、博赫萨生产）对常见口腔微生物的抗菌作用。
材料与方法
在这项体外研究中，制备了四种细菌的分离菌落，包括变形链球菌、血链球菌、唾液链球菌和干酪乳杆菌，用于抗菌漱口水测试。采用试管稀释法测定最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。
结果
使用试管法，对于变形链球菌，金牙龈、博赫萨和博特漱口水的MIC分别为0.14、0.48和1000微克/毫升。上述漱口水对变形链球菌的MBC分别为0.23、1.9和2000微克/毫升。使用试管法，对于血链球菌，金牙龈、博赫萨和博特漱口水的MIC分别为0.073、0.48和250微克/毫升。上述漱口水对血链球菌的MBC分别为0.14、1.9和1000微克/毫升。
结论
金牙龈氯己定漱口水对口腔微生物的作用比博赫萨和博特漱口水更强，建议用于牙菌斑的化学抑制。
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