Ye Y N, So H L, Liu E S L, Shin V Y, Cho C H
Department of Pharmacology, L02-55, 2/F, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, University of Hong Kong, Hong Kong, PR China.
Life Sci. 2003 Jan 10;72(8):925-32. doi: 10.1016/s0024-3205(02)02332-9.
Our previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa. However, there is no report concerning the effect of ASCE on gastric ulcer healing in animal models. In this study, we found that ASCE promoted ulcer healing. The area of the ulcer was reduced. This was accompanied with a significant increase in mucus synthesis when compared with the control. Angiogenesis was inhibited by the treatment of ASCE. Cell proliferation, ODC and EGFR protein expression was not affected in this process. Thus, the mechanism of how ASCE accelerates ulcer healing in addition to its effect on mucus synthesis remains to be investigated.
我们之前的研究表明，当归粗提物（ASCE）主要由多糖组成，能显著促进正常胃上皮细胞的迁移和增殖。这些结果有力地表明，ASCE对胃黏膜具有直接的伤口愈合作用。然而，尚无关于ASCE对动物模型胃溃疡愈合影响的报道。在本研究中，我们发现ASCE促进溃疡愈合。溃疡面积减小。与对照组相比，这伴随着黏液合成的显著增加。ASCE处理可抑制血管生成。在此过程中，细胞增殖、鸟氨酸脱羧酶（ODC）和表皮生长因子受体（EGFR）蛋白表达未受影响。因此，除了其对黏液合成的作用外，ASCE加速溃疡愈合的机制仍有待研究。
