Fujii Chikako, Kawai Toshihide, Azuma Koichiro, Oguma Yuko, Katsukawa Fuminori, Hirose Hiroshi, Tanaka Kumiko, Meguro Shu, Matsumoto Hideo, Itoh Hiroshi
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan.
J Diabetes Res. 2017;2017:1567467. doi: 10.1155/2017/1567467. Epub 2017 Apr 30.
. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. . The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. . The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area ( = -0.411, < 0.0001), fasting glucose ( = -0.330, < 0.0001), HbA1c ( = -0.231, = 0.0146), and systolic blood pressure ( = -0.224, = 0.0184). Linoleic acid percentage was also significantly negatively correlated with HOMA-IR ( = -0.416, < 0.0001) by simple correlation. Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects. The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects. . We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects.
本研究的目的是评估日本人群中游离脂肪酸（FFA）组成与代谢参数（包括体脂分布）之间的关系。研究对象为111名日本患者（54名男性，57名女性）。测量了代谢参数以及通过脐水平CT扫描测定的内脏和皮下脂肪面积。口服75g葡萄糖进行葡萄糖耐量试验（GTT）。FFA中含量最高的亚油酸（C18:2）百分比与内脏脂肪面积呈负相关（r = -0.411，P < 0.0001）、空腹血糖（r = -0.330，P < 0.0001）、糖化血红蛋白（r = -0.231，P = 0.0146）和收缩压（r = -0.224，P = 0.0184）。通过简单相关性分析，亚油酸百分比与HOMA-IR也呈显著负相关（r = -0.416，P < 0.0001）。根据口服葡萄糖耐量试验（OGTT）的结果，将111名受试者分为三组：33名葡萄糖耐量正常者，71名糖耐量受损（IGT）者和7名糖尿病患者。糖尿病患者血清亚油酸百分比显著低于正常受试者。我们得出结论，在日本人群中，血清亚油酸水平与内脏脂肪堆积呈负相关，且与胰岛素抵抗降低有关。
