Schneider H, Reiber W, Sager R, Malek A
Universitäts-Frauenklinik Inselspital, Bern, Switzerland.
Placenta. 2003 Jan;24(1):27-33. doi: 10.1053/plac.2002.0869.
The transplacental flux of glucose together with the consumption by the tissue was studied in human term placenta using the dual in vitro perfusion of an isolated cotyledon. The effect of different transplacental glucose gradients going either from the maternal to the foetal side or in the opposite direction was tested. A linear correlation between uptake from the donor circuit as well as transplacental flux and concentration difference of glucose between the two sides was found in both directions. At comparable gradients both uptake and flux were significantly higher with the gradient going from the maternal to the foetal side as compared to the other direction. For the non-metabolizable 2-deoxy-analog of D -glucose no asymmetry of flux was seen. The large fraction of glucose uptake, which is metabolized by placental tissue together with the difference in membrane transport capacity across the microvillous as compared to the basal membrane of the syncytiotrophoblast could be an explanation for the asymmetry in transplacental glucose flux.
采用离体子叶双体外灌注法，研究了足月人胎盘葡萄糖的跨胎盘通量及其组织消耗量。测试了不同跨胎盘葡萄糖梯度（从母体侧到胎儿侧或相反方向）的影响。在两个方向上均发现，供体循环中的摄取量、跨胎盘通量与两侧葡萄糖浓度差之间呈线性相关。在可比梯度下，与另一个方向相比，从母体侧到胎儿侧的梯度下摄取量和通量均显著更高。对于不可代谢的D-葡萄糖2-脱氧类似物，未观察到通量不对称现象。胎盘组织代谢的大部分葡萄糖摄取量，以及与合体滋养层基底膜相比，微绒毛膜转运能力的差异，可能是跨胎盘葡萄糖通量不对称的一个解释。
