Schiefelbein John
Department of Molecular, Cellular, and Developmental Biology, 830 North University Avenue, University of Michigan, Ann Arbor 48109, USA.
Curr Opin Plant Biol. 2003 Feb;6(1):74-8. doi: 10.1016/s136952660200002x.
The specification of epidermal hairs in Arabidopsis provides a useful model for the study of pattern formation in plants. Although the distributions of hair cells in the root and shoot appear quite different, recent studies show that pattern formation in each relies on a common cassette of transcriptional regulators. During development in each organ, neighboring cells compete to express regulators that specify the primary cell fate (including WEREWOLF [WER]/GLABRA1 [GL1], GL3/bHLH, TRANSPARENT TESTA GLABRA [TTG], and GL2), as well as those that prevent their neighbors from adopting this fate (including CAPRICE [CPC] and TRIPTYCHON [TRY]). The basic mechanism of lateral inhibition with feedback that has been uncovered by recent studies provides a conceptual framework for understanding how patterns of cell fate in general may be specified during plant development.
拟南芥表皮毛的特化提供了一个研究植物模式形成的有用模型。尽管根和地上部分毛细胞的分布看起来有很大不同，但最近的研究表明，每个部位的模式形成都依赖于一组共同的转录调节因子。在每个器官的发育过程中，相邻细胞竞争表达决定主要细胞命运的调节因子（包括狼蛛 [WER]/光皮1 [GL1]、GL3/bHLH、透明种皮光皮 [TTG] 和 GL2），以及那些阻止其邻居采用这种命运的调节因子（包括任性 [CPC] 和三联体 [TRY]）。最近的研究揭示的具有反馈的侧向抑制基本机制，为理解植物发育过程中一般细胞命运模式如何被确定提供了一个概念框架。
