捐赠人乳与配方奶预防早产儿坏死性小肠结肠炎的系统评价

Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review.

作者信息

McGuire W, Anthony M Y

机构信息

Tayside Institute of Child Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK.

出版信息

Arch Dis Child Fetal Neonatal Ed. 2003 Jan;88(1):F11-4. doi: 10.1136/fn.88.1.f11.

DOI:10.1136/fn.88.1.f11

PMID:12496220

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1756003/

Abstract

OBJECTIVES

To determine if enteral feeding with donor human milk compared with formula milk reduces the incidence of necrotising enterocolitis (NEC) in preterm or low birthweight infants.

METHODS

Systematic review and meta-analysis of randomised controlled trials.

RESULTS

Four small trials, all initiated more than 20 years ago, fulfilled the prespecified inclusion criteria. None of the trials individually found any statistically significant difference in the incidence of NEC. However, meta-analysis found that feeding with donor human milk was associated with a significantly reduced relative risk (RR) of NEC. Infants who received donor human milk were three times less likely to develop NEC (RR 0.34; 95% confidence interval (CI) 0.12 to 0.99), and four times less likely to have confirmed NEC (RR 0.25; 95% CI 0.06 to 0.98) than infants who received formula milk.

CONCLUSIONS

It may be appropriate to consider further larger trials to compare growth, development, and the incidence of adverse outcomes, including NEC, in preterm infants who receive donor human milk versus formula milk.

摘要

目的

确定与配方奶相比，给早产或低出生体重婴儿喂食捐赠人乳是否能降低坏死性小肠结肠炎（NEC）的发病率。

方法

对随机对照试验进行系统评价和荟萃分析。

结果

四项小型试验均在20多年前启动，符合预先设定的纳入标准。没有一项试验单独发现NEC发病率有任何统计学上的显著差异。然而，荟萃分析发现，喂食捐赠人乳与NEC的相对风险显著降低有关。与接受配方奶的婴儿相比，接受捐赠人乳的婴儿发生NEC的可能性低三倍（相对风险0.34；95%置信区间[CI]0.12至0.99），确诊NEC的可能性低四倍（相对风险0.25；95%CI0.06至0.98）。