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饮食和营养干预对婴儿肠道微生物组的作用。

The Role of Diet and Nutritional Interventions for the Infant Gut Microbiome.

机构信息

Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Umberto I Hospital, 00161 Rome, Italy.

出版信息

Nutrients. 2024 Jan 30;16(3):400. doi: 10.3390/nu16030400.


DOI:10.3390/nu16030400
PMID:38337684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10857663/
Abstract

The infant gut microbiome plays a key role in the healthy development of the human organism and appears to be influenced by dietary practices through multiple pathways. First, maternal diet during pregnancy and infant nutrition significantly influence the infant gut microbiota. Moreover, breastfeeding fosters the proliferation of beneficial bacteria, while formula feeding increases microbial diversity. The timing of introducing solid foods also influences gut microbiota composition. In preterm infants the gut microbiota development is influenced by multiple factors, including the time since birth and the intake of breast milk, and interventions such as probiotics and prebiotics supplementation show promising results in reducing morbidity and mortality in this population. These findings underscore the need for future research to understand the long-term health impacts of these interventions and for further strategies to enrich the gut microbiome of formula-fed and preterm infants.

摘要

婴儿肠道微生物群在人类机体的健康发育中起着关键作用,并且似乎通过多种途径受到饮食实践的影响。首先,孕妇在怀孕期间的饮食和婴儿营养显著影响婴儿肠道微生物群。此外,母乳喂养促进有益细菌的增殖,而配方奶喂养则增加微生物多样性。引入固体食物的时间也会影响肠道微生物群的组成。在早产儿中,肠道微生物群的发育受到多种因素的影响,包括出生后的时间、母乳的摄入以及益生菌和益生元等干预措施的补充,这些干预措施在降低该人群的发病率和死亡率方面显示出有前景的结果。这些发现强调了未来研究的必要性,以了解这些干预措施的长期健康影响,并制定进一步的策略来丰富配方喂养和早产儿的肠道微生物群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d29/10857663/d8262b645c7f/nutrients-16-00400-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d29/10857663/8e0280ec44f6/nutrients-16-00400-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d29/10857663/d8262b645c7f/nutrients-16-00400-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d29/10857663/8e0280ec44f6/nutrients-16-00400-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d29/10857663/d8262b645c7f/nutrients-16-00400-g002.jpg

相似文献

[1]
The Role of Diet and Nutritional Interventions for the Infant Gut Microbiome.

Nutrients. 2024-1-30

[2]
Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants.

Microbiome. 2016-12-30

[3]
Feeding practice influences gut microbiome composition in very low birth weight preterm infants and the association with oxidative stress: A prospective cohort study.

Free Radic Biol Med. 2019-3-6

[4]
Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants.

J Obstet Gynecol Neonatal Nurs. 2018-5

[5]
Microbiome Composition in Pediatric Populations from Birth to Adolescence: Impact of Diet and Prebiotic and Probiotic Interventions.

Dig Dis Sci. 2020-3

[6]
Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants.

Nurs Res. 2017

[7]
FEEDMI: A Study Protocol to Determine the Influence of Infant-Feeding on Very-Preterm-Infant's Gut Microbiota.

Neonatology. 2019-5-27

[8]
Human Milk Oligosaccharides to Prevent Gut Dysfunction and Necrotizing Enterocolitis in Preterm Neonates.

Nutrients. 2018-10-8

[9]
Exploring the Potential of Human Milk and Formula Milk on Infants' Gut and Health.

Nutrients. 2022-8-29

[10]
Early-Life Gut Microbiome-The Importance of Maternal and Infant Factors in Its Establishment.

Nutr Clin Pract. 2020-6

引用本文的文献

[1]
Gut Microbiota and Its Metabolites Modulate Pregnancy Outcomes by Regulating Placental Autophagy and Ferroptosis.

Antioxidants (Basel). 2025-8-7

[2]
Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring.

Front Cell Neurosci. 2025-8-6

[3]
Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies.

Int J Mol Sci. 2025-7-30

[4]
Microbiota-Modulating Strategies in Neonates Undergoing Surgery for Congenital Gastrointestinal Conditions: A Narrative Review.

Nutrients. 2025-7-5

[5]
Intestinal Microbiota in Early Life: Latest Findings Regarding the Role of Probiotics as a Treatment Approach for Dysbiosis.

Nutrients. 2025-6-21

[6]
The early-life gut microbiome in common pediatric diseases: roles and therapeutic implications.

Front Nutr. 2025-5-29

[7]
Environmental Exposures and the Human Gut Resistome in Northwest Ecuador.

medRxiv. 2025-5-23

[8]
Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring.

Exp Biol Med (Maywood). 2025-5-21

[9]
Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome.

J Clin Med. 2025-3-17

[10]
Impact of diet on the gut mycobiome of Hong Kong Chinese infants.

Comput Struct Biotechnol J. 2025-2-14

本文引用的文献

[1]
Infant Formula Supplemented with Five Human Milk Oligosaccharides Shifts the Fecal Microbiome of Formula-Fed Infants Closer to That of Breastfed Infants.

Nutrients. 2023-7-10

[2]
Bifidobacterium infantis as a probiotic in preterm infants: a systematic review and meta-analysis.

Pediatr Res. 2023-12

[3]
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota.

Nutrients. 2023-5-6

[4]
Bovine milk microbiota: Key players, origins, and potential contributions to early-life gut development.

J Adv Res. 2024-5

[5]
Probiotics for the prevention of mortality and sepsis in preterm very low birth weight neonates from low- and middle-income countries: a Bayesian network meta-analysis.

Front Nutr. 2023-6-14

[6]
The Effect of Breastfeeding on Food Allergies in Newborns and Infants.

Children (Basel). 2023-6-12

[7]
Timely initiation of complementary feeding practices and associated factors among children aged 6-23 months in Dessie Zuria District, Northeast Ethiopia: a community-based cross-sectional study.

Front Pediatr. 2023-6-6

[8]
Comprehensive insights from composition to functional microbe-based biodiversity of the infant human gut microbiota.

NPJ Biofilms Microbiomes. 2023-5-11

[9]
Impact of High-Fiber or High-Protein Diet on the Capacity of Human Gut Microbiota To Produce Tryptophan Catabolites.

J Agric Food Chem. 2023-5-10

[10]
Effect of Maternal Diet on Maternal Milk and Breastfed Infant Gut Microbiomes: A Scoping Review.

Nutrients. 2023-3-15

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