Schramm J Mark, Warner Dave, Hardesty Robert A, Oberg Kerby C
Department of Surgery, Division of Plastic and Reconstructive Surgery, Loma Linda University School of Medicine, Calif 92354, USA.
Plast Reconstr Surg. 2003 Jan;111(1):258-66. doi: 10.1097/01.PRS.0000033065.10876.2E.
Light or electromagnetic radiation has been reported to enhance wound healing. The use of selected spectra, including infrared and microwave, has been described; however, no studies to date have examined the potential benefit of combining these spectra. In this study, a device that emits electromagnetic radiation across both the infrared and microwave ranges was used. To test the effects of this unique electromagnetic radiation spectrum on wound healing, two clinically relevant wound-healing models (i.e., tensile strength of simple incisions and survival of McFarlane flaps) were selected. After the creation of a simple full-thickness incision (n = 35 rats) or a caudally based McFarlane flap (n = 33 rats), animals were randomly assigned to one of three treatment groups: untreated control, infrared, or combined electromagnetic radiation. Treatment was administered for 30 minutes, twice daily for 18 days in animals with simple incisions, and 15 days in animals with McFarlane flaps. The wound area or flap was harvested and analyzed, blinded to the treatment regimens. A p value of less than 0.05 obtained by analysis of variance was considered to be statistically significant. Animals receiving combined electromagnetic radiation demonstrated increased tensile strength (2.62 N/mm2) compared with animals receiving infrared radiation (2.36 N/mm2) or untreated controls (1.73 N/mm2, p < 0.001). Animals with McFarlane flaps receiving combined electromagnetic radiation had increased flap survival (78.0 percent) compared with animals receiving infrared radiation (69.7 percent) and untreated controls (63.1 percent, p < 0.01). Thus, combined electromagnetic radiation provided a distinct advantage in wound healing that might augment current treatment regimens.
据报道，光或电磁辐射可促进伤口愈合。已描述了使用包括红外线和微波在内的特定光谱；然而，迄今为止尚无研究探讨将这些光谱结合使用的潜在益处。在本研究中，使用了一种能发射红外线和微波范围电磁辐射的设备。为了测试这种独特的电磁辐射光谱对伤口愈合的影响，选择了两种临床相关的伤口愈合模型（即简单切口的抗张强度和麦克法兰皮瓣的存活情况）。在制作简单的全层切口（n = 35只大鼠）或尾侧蒂麦克法兰皮瓣（n = 33只大鼠）后，将动物随机分为三个治疗组之一：未治疗对照组、红外线组或联合电磁辐射组。对有简单切口的动物，治疗持续30分钟，每天两次，共18天；对有麦克法兰皮瓣的动物，治疗15天。在对治疗方案不知情的情况下，收集并分析伤口面积或皮瓣情况。通过方差分析获得的p值小于0.05被认为具有统计学意义。与接受红外线辐射的动物（2.36 N/mm²）或未治疗对照组（1.73 N/mm²，p < 0.001）相比，接受联合电磁辐射的动物抗张强度增加（2.62 N/mm²）。与接受红外线辐射的动物（69.7%）和未治疗对照组（63.1%，p < 0.01）相比，接受联合电磁辐射的有麦克法兰皮瓣的动物皮瓣存活率增加（78.0%）。因此，联合电磁辐射在伤口愈合方面具有明显优势，可能会增强当前的治疗方案。
