Schieke S M
Institut für Umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universität gGmbH, and Hautklinik, Universitätsklinikum Düsseldorf.
Hautarzt. 2003 Sep;54(9):822-4. doi: 10.1007/s00105-003-0577-3.
Human skin is exposed to infrared (IR) radiation (760 nm-1 mm) from natural and artificial sources. In particular, the use of IR for cosmetic and "wellness" purposes has become increasingly popular and viewed as completely safe. However, epidemiological data and clinical observations indicate that IR radiation cannot be considered as totally innocuous to human skin. In particular, IR radiation, just as UV radiation, seems to be involved in photoaging and potentially also in photocarcinogenesis. In recent studies the molecular mechanisms involved in this process such as cellular signal transduction and gene expression have been characterised. IR radiation induces the synthesis of matrix metalloproteinase-1 via the mitogen-activated protein kinase signalling pathway. Since this mechanism is a major pathophysiologic factor in UV-induced skin ageing, its activation by IR radiation points to a role of IR in premature skin ageing and indicates the potential need for protection against unwanted IR effects.
人体皮肤会受到来自自然和人工光源的红外（IR）辐射（760纳米至1毫米）。特别是，将红外用于美容和“健康”目的越来越普遍，且被视为完全安全。然而，流行病学数据和临床观察表明，红外辐射对人体皮肤并非完全无害。尤其是，红外辐射与紫外线辐射一样，似乎与光老化有关，甚至可能与光致癌作用有关。在最近的研究中，已经对这一过程中涉及的分子机制，如细胞信号转导和基因表达进行了表征。红外辐射通过丝裂原活化蛋白激酶信号通路诱导基质金属蛋白酶-1的合成。由于这一机制是紫外线诱导皮肤老化的主要病理生理因素，红外辐射对其激活表明红外在皮肤过早老化中起作用，并表明可能需要针对不必要的红外效应进行防护。
