Cole B R, Brocklebank J T, Kienstra R A, Kissane J M, Robson A M
J Pediatr. 1976 Feb;88(2):307-14. doi: 10.1016/s0022-3476(76)81009-8.
Eight patients with severe glomerulonephritis and an average inulin clearance of 21.7 ml/min/1.73 m2 body surface were treated with high-dosage intravenous methylprednisolone, 30 mg/kg given over a one-hour period on each of six alternate days. The mean inulin clearance rate doubled after this "pulse" therapy. In the six patients treated early in the course of their disease, GFR increased to a mean of 100.2 ml/min/1.73 m2 during the follow-up period extending for up to three years and was accompanied by clinical improvement. These observations suggest that "pulse" methylprednisolone may be beneficial in treating some patients with potentially life-threatening severe glomerulonephritis.
八名患有严重肾小球肾炎且菊粉清除率平均为21.7毫升/分钟/1.73平方米体表面积的患者接受了大剂量静脉注射甲基强的松龙治疗，在六个交替日中的每日一小时内给予30毫克/千克。这种“冲击”疗法后，平均菊粉清除率增加了一倍。在病程早期接受治疗的六名患者中，在长达三年的随访期内，肾小球滤过率增加至平均100.2毫升/分钟/1.73平方米，并伴有临床改善。这些观察结果表明，“冲击”甲基强的松龙可能对治疗一些有潜在生命危险的严重肾小球肾炎患者有益。
