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快速进展性IgA肾病

Rapidly progressive IgA nephropathy.

作者信息

Kobayashi Naho, Nishida Masashi, Aoyama Michiko, Yokoi Kentaro, Yahata Tomoyo, Oka Tatsujiro, Sakata Koichi, Shiraishi Isao, Itoi Toshiyuki, Hamaoka Kenji

机构信息

Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan.

Department of Pediatrics, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.

出版信息

Indian J Pediatr. 2005 Mar;72(3):257-260. doi: 10.1007/BF02859270.

Abstract

A 14-year-old boy presented with macroscopic hematuria and a rapid deterioration in renal function. Percutaneous renal biopsy demonstrated severe crescentic IgA nephropathy (IgAN) with extensive (88%) glomerular crescent formation. After started intravenous administration of high-dose pulse methylprednisolone, severe nausea and general malaise accompanied by a rapid increase in Blood Urea Nitrogen (BUN) and serum creatinine levels appeared, however, the renal function ameliorated rapidly and fully revovered by following oral administration of corticosteroid. The clinical presentation of our case seems to be very remarkable compared to previously reported cases of rapidly progressive IgAN.

摘要

一名14岁男孩出现肉眼血尿,肾功能迅速恶化。经皮肾活检显示为严重新月体性IgA肾病(IgAN),肾小球新月体形成广泛(88%)。开始静脉注射大剂量脉冲甲基强的松龙后,出现严重恶心和全身不适,同时血尿素氮(BUN)和血清肌酐水平迅速升高,然而,随后口服皮质类固醇后肾功能迅速改善并完全恢复。与先前报道的快速进展性IgAN病例相比,我们病例的临床表现似乎非常显著。

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